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. 1996 Apr;104(Suppl 2):397–400. doi: 10.1289/ehp.96104s2397

Neurobehavioral epidemiology: application in risk assessment.

P Grandjean 1, R F White 1, P Weihe 1
PMCID: PMC1469607  PMID: 9182047

Abstract

Neurobehavioral epidemiology may contribute information to risk assessment in relation to a) characterization of neurotoxicity and its time course; b) the dose-effect relationship; c) the dose-response relationship; and d) predisposing factors. The quality of this information relies on the validity of the exposure data, the validity and sensitivity of neurobehavioral function tests, and the degree to which sources of bias are controlled. With epidemiologic studies of methylmercury-associated neurotoxicity as an example, the field of research involves numerous uncertainties that should be taken into account in the risk assessment process.

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Selected References

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  1. Bakir F., Damluji S. F., Amin-Zaki L., Murtadha M., Khalidi A., al-Rawi N. Y., Tikriti S., Dahahir H. I., Clarkson T. W., Smith J. C. Methylmercury poisoning in Iraq. Science. 1973 Jul 20;181(4096):230–241. doi: 10.1126/science.181.4096.230. [DOI] [PubMed] [Google Scholar]
  2. Bellinger D. C., Stiles K. M. Epidemiologic approaches to assessing the developmental toxicity of lead. Neurotoxicology. 1993 Summer-Fall;14(2-3):151–160. [PubMed] [Google Scholar]
  3. Cox C., Clarkson T. W., Marsh D. O., Amin-Zaki L., Tikriti S., Myers G. G. Dose-response analysis of infants prenatally exposed to methyl mercury: an application of a single compartment model to single-strand hair analysis. Environ Res. 1989 Aug;49(2):318–332. doi: 10.1016/s0013-9351(89)80075-1. [DOI] [PubMed] [Google Scholar]
  4. Dalgard C, Grandjean P, Jorgensen PJ, Weihe P. Mercury in the Umbilical Cord: Implications for Risk Assessment for Minamata Disease. Environ Health Perspect. 1994 Jun;102(6-7):548–550. doi: 10.1289/ehp.94102548. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Dunn J. D., Clarkson T. W., Magos L. Interaction of ethanol and inorganic mercury: generation of mercury vapor in vivo. J Pharmacol Exp Ther. 1981 Jan;216(1):19–23. [PubMed] [Google Scholar]
  6. Grandjean P., Jørgensen P. J., Weihe P. Human milk as a source of methylmercury exposure in infants. Environ Health Perspect. 1994 Jan;102(1):74–77. doi: 10.1289/ehp.9410274. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Grandjean P., Nielsen G. D., Jørgensen P. J., Hørder M. Reference intervals for trace elements in blood: significance of risk factors. Scand J Clin Lab Invest. 1992 Jun;52(4):321–337. doi: 10.1080/00365519209088366. [DOI] [PubMed] [Google Scholar]
  8. Grandjean P., Sandoe S. H., Kimbrough R. D. Non-specificity of clinical signs and symptoms caused by environmental chemicals. Hum Exp Toxicol. 1991 May;10(3):167–173. doi: 10.1177/096032719101000303. [DOI] [PubMed] [Google Scholar]
  9. Grandjean P., Weihe P., Jørgensen P. J., Clarkson T., Cernichiari E., Viderø T. Impact of maternal seafood diet on fetal exposure to mercury, selenium, and lead. Arch Environ Health. 1992 May-Jun;47(3):185–195. doi: 10.1080/00039896.1992.9938348. [DOI] [PubMed] [Google Scholar]
  10. Grandjean P., Weihe P. Neurobehavioral effects of intrauterine mercury exposure: potential sources of bias. Environ Res. 1993 Apr;61(1):176–183. doi: 10.1006/enrs.1993.1062. [DOI] [PubMed] [Google Scholar]
  11. Grandjean P., Weihe P., White R. F. Milestone development in infants exposed to methylmercury from human milk. Neurotoxicology. 1995 Spring;16(1):27–33. [PubMed] [Google Scholar]
  12. Grandjean P., Wulf H. C., Niebuhr E. Sister chromatid exchange in response to variations in occupational lead exposure. Environ Res. 1983 Oct;32(1):199–204. doi: 10.1016/0013-9351(83)90206-2. [DOI] [PubMed] [Google Scholar]
  13. Hursh J. B., Greenwood M. R., Clarkson T. W., Allen J., Demuth S. The effect of ethanol on the fate of mercury vapor inhaled by man. J Pharmacol Exp Ther. 1980 Sep;214(3):520–527. [PubMed] [Google Scholar]
  14. Lucas A., Morley R., Cole T. J., Gore S. M., Davis J. A., Bamford M. F., Dossetor J. F. Early diet in preterm babies and developmental status in infancy. Arch Dis Child. 1989 Nov;64(11):1570–1578. doi: 10.1136/adc.64.11.1570. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Magos L., Peristianis G. C., Clarkson T. W., Brown A., Preston S., Snowden R. T. Comparative study of the sensitivity of male and female rats to methylmercury. Arch Toxicol. 1981 Aug;48(1):11–20. doi: 10.1007/BF00297071. [DOI] [PubMed] [Google Scholar]
  16. Marsh D. O., Clarkson T. W., Cox C., Myers G. J., Amin-Zaki L., Al-Tikriti S. Fetal methylmercury poisoning. Relationship between concentration in single strands of maternal hair and child effects. Arch Neurol. 1987 Oct;44(10):1017–1022. doi: 10.1001/archneur.1987.00520220023010. [DOI] [PubMed] [Google Scholar]
  17. Nielsen J. B., Andersen O., Grandjean P. Evaluation of mercury in hair, blood and muscle as biomarkers for methylmercury exposure in male and female mice. Arch Toxicol. 1994;68(5):317–321. doi: 10.1007/s002040050075. [DOI] [PubMed] [Google Scholar]
  18. Sackett D. L. Bias in analytic research. J Chronic Dis. 1979;32(1-2):51–63. doi: 10.1016/0021-9681(79)90012-2. [DOI] [PubMed] [Google Scholar]
  19. Seppäläinen A. M., Hernberg S., Vesanto R., Kock B. Early neurotoxic effects of occupational lead exposure: a prospective study. Neurotoxicology. 1983 Summer;4(2):181–192. [PubMed] [Google Scholar]

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