Abstract
We conducted a nested case-control study to prospectively evaluate the relationship of serum estrogens and androgens to risk of breast cancer in postmenopausal women. From 1977 to 1987, 3375 postmenopausal women free of cancer and not taking replacement estrogens donated blood to the Breast Cancer Serum Bank in Columbia, Missouri. Of these, 72 were subsequently diagnosed with breast cancer. For each case, two controls matched on age and date and time of day of blood collection were selected using incidence density matching. The median age of subjects at blood collection was 62 years; the time from blood collection to diagnosis ranged from less than 1 to 9.5 years with a median of 2.9 years. Risk of breast cancer was positively and significantly associated with serum levels of estrogens and androgens. Compared to women in the lowest quartile, those in the highest quartile for non-sex hormone-binding globulin (non-SHBG) bound (bioavailable) estradiol had a relative risk of 5.2 (95% confidence interval [CI] = 1.5-18.5) and those in the highest quartile for testosterone had a relative risk of 6.2 (95% CI = 2.0-19.0). Our results lend considerable support to the hypothesis that serum concentrations of estrogens and androgens are related to the subsequent diagnosis of breast cancer in postmenopausal women.
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- Berrino F., Muti P., Micheli A., Bolelli G., Krogh V., Sciajno R., Pisani P., Panico S., Secreto G. Serum sex hormone levels after menopause and subsequent breast cancer. J Natl Cancer Inst. 1996 Mar 6;88(5):291–296. doi: 10.1093/jnci/88.5.291. [DOI] [PubMed] [Google Scholar]
- Dorgan J. F., Longcope C., Stephenson H. E., Jr, Falk R. T., Miller R., Franz C., Kahle L., Campbell W. S., Tangrea J. A., Schatzkin A. Relation of prediagnostic serum estrogen and androgen levels to breast cancer risk. Cancer Epidemiol Biomarkers Prev. 1996 Jul;5(7):533–539. [PubMed] [Google Scholar]
- Garland C. F., Friedlander N. J., Barrett-Connor E., Khaw K. T. Sex hormones and postmenopausal breast cancer: a prospective study in an adult community. Am J Epidemiol. 1992 Jun 1;135(11):1220–1230. doi: 10.1093/oxfordjournals.aje.a116228. [DOI] [PubMed] [Google Scholar]
- Helzlsouer K. J., Alberg A. J., Bush T. L., Longcope C., Gordon G. B., Comstock G. W. A prospective study of endogenous hormones and breast cancer. Cancer Detect Prev. 1994;18(2):79–85. [PubMed] [Google Scholar]
- Kelsey J. L. Breast cancer epidemiology: summary and future directions. Epidemiol Rev. 1993;15(1):256–263. doi: 10.1093/oxfordjournals.epirev.a036112. [DOI] [PubMed] [Google Scholar]
- Longcope C., Franz C., Morello C., Baker R., Johnston C. C., Jr Steroid and gonadotropin levels in women during the peri-menopausal years. Maturitas. 1986 Oct;8(3):189–196. doi: 10.1016/0378-5122(86)90025-3. [DOI] [PubMed] [Google Scholar]
- Longcope C., Hui S. L., Johnston C. C., Jr Free estradiol, free testosterone, and sex hormone-binding globulin in perimenopausal women. J Clin Endocrinol Metab. 1987 Mar;64(3):513–518. doi: 10.1210/jcem-64-3-513. [DOI] [PubMed] [Google Scholar]
- Toniolo P. G., Levitz M., Zeleniuch-Jacquotte A., Banerjee S., Koenig K. L., Shore R. E., Strax P., Pasternack B. S. A prospective study of endogenous estrogens and breast cancer in postmenopausal women. J Natl Cancer Inst. 1995 Feb 1;87(3):190–197. doi: 10.1093/jnci/87.3.190. [DOI] [PubMed] [Google Scholar]
- Wysowski D. K., Comstock G. W., Helsing K. J., Lau H. L. Sex hormone levels in serum in relation to the development of breast cancer. Am J Epidemiol. 1987 May;125(5):791–799. doi: 10.1093/oxfordjournals.aje.a114596. [DOI] [PubMed] [Google Scholar]