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. 1997 Dec;105(Suppl 6):1523–1527. doi: 10.1289/ehp.97105s61523

Lessons learned from the study of immigrants to Israel from areas of Russia, Belarus, and Ukraine contaminated by the Chernobyl accident.

M R Quastel 1, J R Goldsmith 1, J Cwikel 1, L Merkin 1, V Y Wishkerman 1, S Poljak 1, A Abdelgani 1, E Kordysh 1, A Douvdevani 1, J Levy 1, R Gorodisher 1, Y Barki 1, I Emerit 1, G Kramer 1
PMCID: PMC1469938  PMID: 9467076

Abstract

During the past 6 years, immigration to Israel of 700,000 persons from the former Soviet Union (FSU) included about 140,000 from radiocontaminated regions of Belarus, Ukraine, and Russia near Chernobyl. In Beer Sheva, a major center for immigrant absorption in Israel, a primary objective was to evaluate their health status and to refer them for care. 137Cs levels in 1228 men, women, and children were measured with a portable whole-body counter. Whole-body counts showed clear correlation with the degree of 137Cs ground contamination in previous regions of residence. The population could thus be sub-divided according to degree of exposure, based on previous regions of residence. The thyroid status of 300 local immigrant children was evaluated because of the increased risk of childhood thyroid cancer in the regions from which they came. This group was subdivided into comparative groups of children who came from less and more contaminated areas according to the International Atomic Energy Agency soil 137Cs contamination maps. Enlarged thyroids were found in about 40% of both groups. One 12-year-old girl from Gomel had a malignant papillary carcinoma. Thyroid-stimulating hormone levels, though within normal limits, were significantly greater (p < 0.02) for girls from high exposure regions. Liquidators showed significant increases in serum clastogenic factor and in the number of circulating glycophorin A-mutated red cells. In studies of over 700 people from both radiocontaminated and unaffected regions of the FSU, evidence for posttraumatic stress disorder was found more frequently in persons coming from the more contaminated areas.

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Selected References

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  1. Abelin T., Averkin J. I., Egger M., Egloff B., Furmanchuk A. W., Gurtner F., Korotkevich J. A., Marx A., Matveyenko I. I., Okeanov A. E. Thyroid cancer in Belarus post-Chernobyl: improved detection or increased incidence? Soz Praventivmed. 1994;39(4):189–197. doi: 10.1007/BF01309218. [DOI] [PubMed] [Google Scholar]
  2. Akiyama M., Umeki S., Kusunoki Y., Kyoizumi S., Nakamura N., Mori T., Ishikawa Y., Yamakido M., Ohama K., Kodama T. Somatic-cell mutations as a possible predictor of cancer risk. Health Phys. 1995 May;68(5):643–649. doi: 10.1097/00004032-199505000-00003. [DOI] [PubMed] [Google Scholar]
  3. Anspaugh L. R., Catlin R. J., Goldman M. The global impact of the Chernobyl reactor accident. Science. 1988 Dec 16;242(4885):1513–1519. doi: 10.1126/science.3201240. [DOI] [PubMed] [Google Scholar]
  4. Baverstock K., Egloff B., Pinchera A., Ruchti C., Williams D. Thyroid cancer after Chernobyl. Nature. 1992 Sep 3;359(6390):21–22. doi: 10.1038/359021b0. [DOI] [PubMed] [Google Scholar]
  5. Bigbee W. L., Jensen R. H., Veidebaum T., Tekkel M., Rahu M., Stengrevics A., Auvinen A., Hakulinen T., Servomaa K., Rytömaa T. Biodosimetry of Chernobyl cleanup workers from Estonia and Latvia using the glycophorin A in vivo somatic cell mutation assay. Radiat Res. 1997 Feb;147(2):215–224. [PubMed] [Google Scholar]
  6. Bigbee W. L., Jensen R. H., Veidebaum T., Tekkel M., Rahu M., Stengrevics A., Kesminiene A., Kurtinaitis J., Auvinen A., Hakulinen T. Glycophorin A biodosimetry in Chernobyl cleanup workers from the Baltic countries. BMJ. 1996 Apr 27;312(7038):1078–1079. doi: 10.1136/bmj.312.7038.1078. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Bigbee W. L., Langlois R. G., Swift M., Jensen R. H. Evidence for an elevated frequency of in vivo somatic cell mutations in ataxia telangiectasia. Am J Hum Genet. 1989 Mar;44(3):402–408. [PMC free article] [PubMed] [Google Scholar]
  8. Bigbee W. L., Wyrobek A. J., Langlois R. G., Jensen R. H., Everson R. B. The effect of chemotherapy on the in vivo frequency of glycophorin A 'null' variant erythrocytes. Mutat Res. 1990 Mar;240(3):165–175. doi: 10.1016/0165-1218(90)90056-8. [DOI] [PubMed] [Google Scholar]
  9. Cwikel J., Abdelgani A., Goldsmith J. R., Quastel M., Yevelson I. I. Two-year follow up study of stress-related disorders among immigrants to Israel from the Chernobyl area. Environ Health Perspect. 1997 Dec;105 (Suppl 6):1545–1550. doi: 10.1289/ehp.97105s61545. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Emerit I., Levy A., Cernjavski L., Arutyunyan R., Oganesyan N., Pogosian A., Mejlumian H., Sarkisian T., Gulkandanian M., Quastel M. Transferable clastogenic activity in plasma from persons exposed as salvage personnel of the Chernobyl reactor. J Cancer Res Clin Oncol. 1994;120(9):558–561. doi: 10.1007/BF01221035. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Emerit I., Quastel M., Goldsmith J., Merkin L., Levy A., Cernjavski L., Alaoui-Youssefi A., Pogossian A., Riklis E. Clastogenic factors in the plasma of children exposed at Chernobyl. Mutat Res. 1997 Jan 3;373(1):47–54. doi: 10.1016/s0027-5107(96)00187-x. [DOI] [PubMed] [Google Scholar]
  12. Emerit I. Reactive oxygen species, chromosome mutation, and cancer: possible role of clastogenic factors in carcinogenesis. Free Radic Biol Med. 1994 Jan;16(1):99–109. doi: 10.1016/0891-5849(94)90246-1. [DOI] [PubMed] [Google Scholar]
  13. Goldsmith JR, Merkin L, Quastel MR, Poljak S, Kordysh EA, Wishkerman V, V, Emerit I., I Evaluation of the Radiation Exposures of Chernobyl "Liquidators": Exploratory Studies of a Sample of Immigrants to Israel. Int J Occup Environ Health. 1997 Jan;3(1):51–59. doi: 10.1179/oeh.1997.3.1.51. [DOI] [PubMed] [Google Scholar]
  14. Hollowell J. G., Jr, Littlefield L. G. Chromosome damage induced by plasma of x-rayed patients: an indirect effect of x-ray. Proc Soc Exp Biol Med. 1968 Oct;129(1):240–244. doi: 10.3181/00379727-129-33295. [DOI] [PubMed] [Google Scholar]
  15. Jensen R. H., Langlois R. G., Bigbee W. L., Grant S. G., Moore D., 2nd, Pilinskaya M., Vorobtsova I., Pleshanov P. Elevated frequency of glycophorin A mutations in erythrocytes from Chernobyl accident victims. Radiat Res. 1995 Feb;141(2):129–135. [PubMed] [Google Scholar]
  16. Kazakov V. S., Demidchik E. P., Astakhova L. N. Thyroid cancer after Chernobyl. Nature. 1992 Sep 3;359(6390):21–21. doi: 10.1038/359021a0. [DOI] [PubMed] [Google Scholar]
  17. Kordysh E. A., Goldsmith J. R., Quastel M. R., Poljak S., Merkin L., Cohen R., Gorodischer R. Health effects in a casual sample of immigrants to Israel from areas contaminated by the Chernobyl explosion. Environ Health Perspect. 1995 Oct;103(10):936–941. doi: 10.1289/ehp.95103936. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Kyoizumi S., Akiyama M., Cologne J. B., Tanabe K., Nakamura N., Awa A. A., Hirai Y., Kusunoki Y., Umeki S. Somatic cell mutations at the glycophorin A locus in erythrocytes of atomic bomb survivors: implications for radiation carcinogenesis. Radiat Res. 1996 Jul;146(1):43–52. [PubMed] [Google Scholar]
  19. Kyoizumi S., Nakamura N., Hakoda M., Awa A. A., Bean M. A., Jensen R. H., Akiyama M. Detection of somatic mutations at the glycophorin A locus in erythrocytes of atomic bomb survivors using a single beam flow sorter. Cancer Res. 1989 Feb 1;49(3):581–588. [PubMed] [Google Scholar]
  20. Langlois R. G., Bigbee W. L., Jensen R. H., German J. Evidence for increased in vivo mutation and somatic recombination in Bloom's syndrome. Proc Natl Acad Sci U S A. 1989 Jan;86(2):670–674. doi: 10.1073/pnas.86.2.670. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. Langlois R. G., Bigbee W. L., Jensen R. H. Measurements of the frequency of human erythrocytes with gene expression loss phenotypes at the glycophorin A locus. Hum Genet. 1986 Dec;74(4):353–362. doi: 10.1007/BF00280485. [DOI] [PubMed] [Google Scholar]
  22. Langlois R. G., Bigbee W. L., Kyoizumi S., Nakamura N., Bean M. A., Akiyama M., Jensen R. H. Evidence for increased somatic cell mutations at the glycophorin A locus in atomic bomb survivors. Science. 1987 Apr 24;236(4800):445–448. doi: 10.1126/science.3563520. [DOI] [PubMed] [Google Scholar]
  23. Langlois R. G., Nisbet B. A., Bigbee W. L., Ridinger D. N., Jensen R. H. An improved flow cytometric assay for somatic mutations at the glycophorin A locus in humans. Cytometry. 1990;11(4):513–521. doi: 10.1002/cyto.990110410. [DOI] [PubMed] [Google Scholar]
  24. Likhtarev I. A., Sobolev B. G., Kairo I. A., Tronko N. D., Bogdanova T. I., Oleinic V. A., Epshtein E. V., Beral V. Thyroid cancer in the Ukraine. Nature. 1995 Jun 1;375(6530):365–365. doi: 10.1038/375365a0. [DOI] [PubMed] [Google Scholar]
  25. Mityukova T. A., Astakhova L. N., Asenchyk L. D., Orlov M. M., VanMiddlesworth L. Urinary iodine excretion in Belarus children. Eur J Endocrinol. 1995 Aug;133(2):216–217. doi: 10.1530/eje.0.1330216. [DOI] [PubMed] [Google Scholar]
  26. Quastel M. R., Goldsmith J. R., Mirkin L., Poljak S., Barki Y., Levy J., Gorodischer R. Thyroid-stimulating hormone levels in children from Chernobyl. Environ Health Perspect. 1997 Dec;105 (Suppl 6):1497–1498. doi: 10.1289/ehp.97105s61497. [DOI] [PMC free article] [PubMed] [Google Scholar]
  27. Quastel M. R., Kramer G. H., Goldsmith J. R., Polyak S., Kordysh E., Noel L., Cohen R., Gorodisher R. Radiocesium body burdens in immigrants to Israel from areas of the Ukraine, Belarus and Russia near Chernobyl. Health Phys. 1995 Jul;69(1):102–110. doi: 10.1097/00004032-199507000-00010. [DOI] [PubMed] [Google Scholar]
  28. Straume T., Langlois R. G., Lucas J., Jensen R. H., Bigbee W. L., Ramalho A. T., Brandão-Mello C. E. Novel biodosimetry methods applied to victims of the Goiânia accident. Health Phys. 1991 Jan;60(1):71–76. doi: 10.1097/00004032-199101000-00011. [DOI] [PubMed] [Google Scholar]
  29. Sugenoya A., Asanuma K., Hama Y., Masuda H., Skidanenko G. S., Anatoliebna A. T., Koike K., Komiyama A., Iida F. Thyroid abnormalities among children in the contaminated area related to the Chernobyl accident. Thyroid. 1995 Feb;5(1):29–33. doi: 10.1089/thy.1995.5.29. [DOI] [PubMed] [Google Scholar]
  30. Williams D. Epidemiology. Chernobyl, eight years on. Nature. 1994 Oct 13;371(6498):556–556. doi: 10.1038/371556a0. [DOI] [PubMed] [Google Scholar]
  31. Williams D. Thyroid cancer and the Chernobyl accident. J Clin Endocrinol Metab. 1996 Jan;81(1):6–8. doi: 10.1210/jcem.81.1.8550795. [DOI] [PubMed] [Google Scholar]
  32. Wishkerman V. Y., Quastel M. R., Douvdevani A., Goldsmith J. R. Somatic mutations at the glycophorin A (GPA) locus measured in red cells of Chernobyl liquidators who immigrated to Israel. Environ Health Perspect. 1997 Dec;105 (Suppl 6):1451–1454. doi: 10.1289/ehp.97105s61451. [DOI] [PMC free article] [PubMed] [Google Scholar]

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