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. 1997 Oct;105(10):1068–1077. doi: 10.1289/ehp.971051068

Pesticides and childhood cancers.

J L Daniels 1, A F Olshan 1, D A Savitz 1
PMCID: PMC1470375  PMID: 9349828

Abstract

To evaluate the possible association between pesticides and the risk of childhood cancers, epidemiologic studies published between 1970 and 1996 were critically reviewed. Thirty-one studies investigated whether occupational or residential exposure to pesticides by either parents or children was related to increased risk of childhood cancer. In general, the reported relative risk estimates were modest. Risk estimates appeared to be stronger when pesticide exposure was measured in more detail. Frequent occupational exposure to pesticides or home pesticide use was more strongly associated with both childhood leukemia and brain cancer than either professional exterminations or the use of garden pesticides. Occupational pesticide exposure was also associated with increased risk of Wilms' tumor, Ewing's sarcoma, and germ cell tumors. Residence on a farm, a proxy for pesticide exposure, was associated with increased risk of a number of childhood cancers. Although increased risk of some childhood cancers in association with pesticide exposure is suggested by multiple studies, methodological limitations common to many studies restrict conclusions; these include indirect exposure classification, small sample size, and potential biases in control selection. Opportunities for methodologic improvement in future studies of pesticides and childhood cancers are described.

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Selected References

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  1. Blair A., Zahm S. H. Methodologic issues in exposure assessment for case-control studies of cancer and herbicides. Am J Ind Med. 1990;18(3):285–293. doi: 10.1002/ajim.4700180308. [DOI] [PubMed] [Google Scholar]
  2. Buckley J. D., Robison L. L., Swotinsky R., Garabrant D. H., LeBeau M., Manchester P., Nesbit M. E., Odom L., Peters J. M., Woods W. G. Occupational exposures of parents of children with acute nonlymphocytic leukemia: a report from the Childrens Cancer Study Group. Cancer Res. 1989 Jul 15;49(14):4030–4037. [PubMed] [Google Scholar]
  3. Bunin G. R., Buckley J. D., Boesel C. P., Rorke L. B., Meadows A. T. Risk factors for astrocytic glioma and primitive neuroectodermal tumor of the brain in young children: a report from the Children's Cancer Group. Cancer Epidemiol Biomarkers Prev. 1994 Apr-May;3(3):197–204. [PubMed] [Google Scholar]
  4. Bunin G. R., Ward E., Kramer S., Rhee C. A., Meadows A. T. Neuroblastoma and parental occupation. Am J Epidemiol. 1990 May;131(5):776–780. doi: 10.1093/oxfordjournals.aje.a115568. [DOI] [PubMed] [Google Scholar]
  5. Colborn T. The wildlife/human connection: modernizing risk decisions. Environ Health Perspect. 1994 Dec;102 (Suppl 12):55–59. doi: 10.1289/ehp.94102s1255a. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Colborn T., vom Saal F. S., Soto A. M. Developmental effects of endocrine-disrupting chemicals in wildlife and humans. Environ Health Perspect. 1993 Oct;101(5):378–384. doi: 10.1289/ehp.93101378. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Coppes M. J., Haber D. A., Grundy P. E. Genetic events in the development of Wilms' tumor. N Engl J Med. 1994 Sep 1;331(9):586–590. doi: 10.1056/NEJM199409013310906. [DOI] [PubMed] [Google Scholar]
  8. Davis J. R., Brownson R. C., Garcia R., Bentz B. J., Turner A. Family pesticide use and childhood brain cancer. Arch Environ Contam Toxicol. 1993 Jan;24(1):87–92. doi: 10.1007/BF01061094. [DOI] [PubMed] [Google Scholar]
  9. Davis J. R., Brownson R. C., Garcia R. Family pesticide use in the home, garden, orchard, and yard. Arch Environ Contam Toxicol. 1992 Apr;22(3):260–266. doi: 10.1007/BF00212083. [DOI] [PubMed] [Google Scholar]
  10. Fabia J., Thuy T. D. Occupation of father at time of birth of children dying of malignant diseases. Br J Prev Soc Med. 1974 May;28(2):98–100. doi: 10.1136/jech.28.2.98. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Fox R. R., Diwan B. A., Meier H. Transplacental induction of primary renal tumors in rabbits treated with 1-ethyl-1-nitrosourea. J Natl Cancer Inst. 1975 Jun;54(6):1439–1448. doi: 10.1093/jnci/54.6.1439. [DOI] [PubMed] [Google Scholar]
  12. Fritschi L., Siemiatycki J., Richardson L. Self-assessed versus expert-assessed occupational exposures. Am J Epidemiol. 1996 Sep 1;144(5):521–527. doi: 10.1093/oxfordjournals.aje.a008959. [DOI] [PubMed] [Google Scholar]
  13. Gold E. B., Diener M. D., Szklo M. Parental occupations and cancer in children--a case-control study and review of the methodologic issues. J Occup Med. 1982 Aug;24(8):578–584. [PubMed] [Google Scholar]
  14. Gold E., Gordis L., Tonascia J., Szklo M. Risk factors for brain tumors in children. Am J Epidemiol. 1979 Mar;109(3):309–319. doi: 10.1093/oxfordjournals.aje.a112684. [DOI] [PubMed] [Google Scholar]
  15. Grufferman S., Wang H. H., DeLong E. R., Kimm S. Y., Delzell E. S., Falletta J. M. Environmental factors in the etiology of rhabdomyosarcoma in childhood. J Natl Cancer Inst. 1982 Jan;68(1):107–113. [PubMed] [Google Scholar]
  16. Gurney J. G., Davis S., Severson R. K., Fang J. Y., Ross J. A., Robison L. L. Trends in cancer incidence among children in the U.S. Cancer. 1996 Aug 1;78(3):532–541. doi: 10.1002/(SICI)1097-0142(19960801)78:3<532::AID-CNCR22>3.0.CO;2-Z. [DOI] [PubMed] [Google Scholar]
  17. Hemminki K., Saloniemi I., Salonen T., Partanen T., Vainio H. Childhood cancer and parental occupation in Finland. J Epidemiol Community Health. 1981 Mar;35(1):11–15. doi: 10.1136/jech.35.1.11. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Hodgson E., Levi P. E. Pesticides: an important but underused model for the environmental health sciences. Environ Health Perspect. 1996 Mar;104 (Suppl 1):97–106. doi: 10.1289/ehp.96104s197. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Holliday R. The inheritance of epigenetic defects. Science. 1987 Oct 9;238(4824):163–170. doi: 10.1126/science.3310230. [DOI] [PubMed] [Google Scholar]
  20. Holly E. A., Aston D. A., Ahn D. K., Kristiansen J. J. Ewing's bone sarcoma, paternal occupational exposure, and other factors. Am J Epidemiol. 1992 Jan 15;135(2):122–129. doi: 10.1093/oxfordjournals.aje.a116265. [DOI] [PubMed] [Google Scholar]
  21. Howe G. R., Burch J. D., Chiarelli A. M., Risch H. A., Choi B. C. An exploratory case-control study of brain tumors in children. Cancer Res. 1989 Aug 1;49(15):4349–4352. [PubMed] [Google Scholar]
  22. Infante-Rivard C., Mur P., Armstrong B., Alvarez-Dardet C., Bolumar F. Acute lymphoblastic leukaemia among Spanish children and mothers' occupation: a case-control study. J Epidemiol Community Health. 1991 Mar;45(1):11–15. doi: 10.1136/jech.45.1.11. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. Knudson A. G., Jr Mutation and cancer: statistical study of retinoblastoma. Proc Natl Acad Sci U S A. 1971 Apr;68(4):820–823. doi: 10.1073/pnas.68.4.820. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. Knudson A. G., Jr, Strong L. C. Mutation and cancer: a model for Wilms' tumor of the kidney. J Natl Cancer Inst. 1972 Feb;48(2):313–324. [PubMed] [Google Scholar]
  25. Kristensen P., Andersen A., Irgens L. M., Bye A. S., Sundheim L. Cancer in offspring of parents engaged in agricultural activities in Norway: incidence and risk factors in the farm environment. Int J Cancer. 1996 Jan 3;65(1):39–50. doi: 10.1002/(SICI)1097-0215(19960103)65:1<39::AID-IJC8>3.0.CO;2-2. [DOI] [PubMed] [Google Scholar]
  26. Kuijten R. R., Bunin G. R., Nass C. C., Meadows A. T. Parental occupation and childhood astrocytoma: results of a case-control study. Cancer Res. 1992 Feb 15;52(4):782–786. [PubMed] [Google Scholar]
  27. Laval G., Tuyns A. J. Environmental factors in childhood leukaemia. Br J Ind Med. 1988 Dec;45(12):843–844. doi: 10.1136/oem.45.12.843. [DOI] [PMC free article] [PubMed] [Google Scholar]
  28. Leiss J. K., Savitz D. A. Home pesticide use and childhood cancer: a case-control study. Am J Public Health. 1995 Feb;85(2):249–252. doi: 10.2105/ajph.85.2.249. [DOI] [PMC free article] [PubMed] [Google Scholar]
  29. Lowengart R. A., Peters J. M., Cicioni C., Buckley J., Bernstein L., Preston-Martin S., Rappaport E. Childhood leukemia and parents' occupational and home exposures. J Natl Cancer Inst. 1987 Jul;79(1):39–46. [PubMed] [Google Scholar]
  30. Nanni O., Ricci M., Lugaresi C., Amadori D., Falcini F., Buiatti E. Iterative use of a priori exposure matrices to improve the characterization of chemical exposures in agricultural work studies. Scand J Work Environ Health. 1993 Jun;19(3):191–199. doi: 10.5271/sjweh.1482. [DOI] [PubMed] [Google Scholar]
  31. Nomura T. Parental exposure to x rays and chemicals induces heritable tumours and anomalies in mice. Nature. 1982 Apr 8;296(5857):575–577. doi: 10.1038/296575a0. [DOI] [PubMed] [Google Scholar]
  32. O'Leary L. M., Hicks A. M., Peters J. M., London S. Parental occupational exposures and risk of childhood cancer: a review. Am J Ind Med. 1991;20(1):17–35. doi: 10.1002/ajim.4700200103. [DOI] [PubMed] [Google Scholar]
  33. Olsen J. H., de Nully Brown P., Schulgen G., Jensen O. M. Parental employment at time of conception and risk of cancer in offspring. Eur J Cancer. 1991;27(8):958–965. doi: 10.1016/0277-5379(91)90258-f. [DOI] [PubMed] [Google Scholar]
  34. Olshan A. F., Breslow N. E., Falletta J. M., Grufferman S., Pendergrass T., Robison L. L., Waskerwitz M., Woods W. G., Vietti T. J., Hammond G. D. Risk factors for Wilms tumor. Report from the National Wilms Tumor Study. Cancer. 1993 Aug 1;72(3):938–944. doi: 10.1002/1097-0142(19930801)72:3<938::aid-cncr2820720345>3.0.co;2-c. [DOI] [PubMed] [Google Scholar]
  35. Preston-Martin S., Yu M. C., Benton B., Henderson B. E. N-Nitroso compounds and childhood brain tumors: a case-control study. Cancer Res. 1982 Dec;42(12):5240–5245. [PubMed] [Google Scholar]
  36. Robison L. L., Buckley J. D., Bunin G. Assessment of environmental and genetic factors in the etiology of childhood cancers: the Childrens Cancer Group epidemiology program. Environ Health Perspect. 1995 Sep;103 (Suppl 6):111–116. doi: 10.1289/ehp.95103s6111. [DOI] [PMC free article] [PubMed] [Google Scholar]
  37. Sakkinen P. A., Severson R. K., Ross J. A., Robison L. L. Random-digit dialing for control selection in childhood cancer studies: the geographic proximity and demographics within matched sets. Am J Public Health. 1995 Apr;85(4):555–557. doi: 10.2105/ajph.85.4.555. [DOI] [PMC free article] [PubMed] [Google Scholar]
  38. Sanders B. M., White G. C., Draper G. J. Occupations of fathers of children dying from neoplasms. J Epidemiol Community Health. 1981 Dec;35(4):245–250. doi: 10.1136/jech.35.4.245. [DOI] [PMC free article] [PubMed] [Google Scholar]
  39. Savage E. P., Keefe T. J., Wheeler H. W., Mounce L., Helwic L., Applehans F., Goes E., Goes T., Mihlan G., Rench J. Household pesticide usage in the United States. Arch Environ Health. 1981 Nov-Dec;36(6):304–309. doi: 10.1080/00039896.1981.10667642. [DOI] [PubMed] [Google Scholar]
  40. Savitz D. A., Chen J. H. Parental occupation and childhood cancer: review of epidemiologic studies. Environ Health Perspect. 1990 Aug;88:325–337. doi: 10.1289/ehp.9088325. [DOI] [PMC free article] [PubMed] [Google Scholar]
  41. Schnitzer P. G., Olshan A. F., Savitz D. A., Erickson J. D. Validity of mother's report of father's occupation in a study of paternal occupation and congenital malformations. Am J Epidemiol. 1995 May 1;141(9):872–877. doi: 10.1093/oxfordjournals.aje.a117523. [DOI] [PubMed] [Google Scholar]
  42. Schwartzbaum J. A., George S. L., Pratt C. B., Davis B. An exploratory study of environmental and medical factors potentially related to childhood cancer. Med Pediatr Oncol. 1991;19(2):115–121. doi: 10.1002/mpo.2950190209. [DOI] [PubMed] [Google Scholar]
  43. Sexton K., Selevan S. G., Wagener D. K., Lybarger J. A. Estimating human exposures to environmental pollutants: availability and utility of existing databases. Arch Environ Health. 1992 Nov-Dec;47(6):398–407. doi: 10.1080/00039896.1992.9938381. [DOI] [PubMed] [Google Scholar]
  44. Sharpe C. R., Franco E. L., de Camargo B., Lopes L. F., Barreto J. H., Johnsson R. R., Mauad M. A. Parental exposures to pesticides and risk of Wilms' tumor in Brazil. Am J Epidemiol. 1995 Feb 1;141(3):210–217. doi: 10.1093/oxfordjournals.aje.a117422. [DOI] [PubMed] [Google Scholar]
  45. Shu X. O., Gao Y. T., Brinton L. A., Linet M. S., Tu J. T., Zheng W., Fraumeni J. F., Jr A population-based case-control study of childhood leukemia in Shanghai. Cancer. 1988 Aug 1;62(3):635–644. doi: 10.1002/1097-0142(19880801)62:3<635::aid-cncr2820620332>3.0.co;2-3. [DOI] [PubMed] [Google Scholar]
  46. Shu X. O., Nesbit M. E., Buckley J. D., Krailo M. D., Robinson L. L. An exploratory analysis of risk factors for childhood malignant germ-cell tumors: report from the Childrens Cancer Group (Canada, United States). Cancer Causes Control. 1995 May;6(3):187–198. doi: 10.1007/BF00051790. [DOI] [PubMed] [Google Scholar]
  47. Spitz M. R., Johnson C. C. Neuroblastoma and paternal occupation. A case-control analysis. Am J Epidemiol. 1985 Jun;121(6):924–929. doi: 10.1093/oxfordjournals.aje.a114062. [DOI] [PubMed] [Google Scholar]
  48. Stewart W. F., Stewart P. A. Occupational case-control studies: I. Collecting information on work histories and work-related exposures. Am J Ind Med. 1994 Sep;26(3):297–312. doi: 10.1002/ajim.4700260304. [DOI] [PubMed] [Google Scholar]
  49. Teschke K., Kennedy S. M., Olshan A. F. Effect of different questionnaire formats on reporting of occupational exposures. Am J Ind Med. 1994 Sep;26(3):327–337. doi: 10.1002/ajim.4700260306. [DOI] [PubMed] [Google Scholar]
  50. Tomatis L., Cabral J. R., Likhachev A. J., Ponomarkov V. Increased cancer incidence in the progeny of male rats exposed to ethylnitrosourea before mating. Int J Cancer. 1981 Oct 15;28(4):475–478. doi: 10.1002/ijc.2910280413. [DOI] [PubMed] [Google Scholar]
  51. Tomatis L., Narod S., Yamasaki H. Transgeneration transmission of carcinogenic risk. Carcinogenesis. 1992 Feb;13(2):145–151. doi: 10.1093/carcin/13.2.145. [DOI] [PubMed] [Google Scholar]
  52. Werler M. M., Pober B. R., Nelson K., Holmes L. B. Reporting accuracy among mothers of malformed and nonmalformed infants. Am J Epidemiol. 1989 Feb;129(2):415–421. doi: 10.1093/oxfordjournals.aje.a115145. [DOI] [PubMed] [Google Scholar]
  53. Wilkins J. R., 3rd, Koutras R. A. Paternal occupation and brain cancer in offspring: a mortality-based case-control study. Am J Ind Med. 1988;14(3):299–318. doi: 10.1002/ajim.4700140308. [DOI] [PubMed] [Google Scholar]
  54. Wilkins J. R., 3rd, Sinks T. H., Jr Occupational exposures among fathers of children with Wilms' tumor. J Occup Med. 1984 Jun;26(6):427–435. doi: 10.1097/00043764-198406000-00015. [DOI] [PubMed] [Google Scholar]
  55. Wilkins J. R., 3rd, Sinks T. Parental occupation and intracranial neoplasms of childhood: results of a case-control interview study. Am J Epidemiol. 1990 Aug;132(2):275–292. doi: 10.1093/oxfordjournals.aje.a115657. [DOI] [PubMed] [Google Scholar]
  56. van Steensel-Moll H. A., Valkenburg H. A., van Zanen G. E. Childhood leukemia and parental occupation. A register-based case-control study. Am J Epidemiol. 1985 Feb;121(2):216–224. doi: 10.1093/oxfordjournals.aje.a113992. [DOI] [PubMed] [Google Scholar]

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