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. 2004 May;167(1):263–273. doi: 10.1534/genetics.167.1.263

Mutational analysis of the Drosophila DNA repair and recombination gene mei-9.

Ozlem Yildiz 1, Hutton Kearney 1, Benjamin C Kramer 1, Jeff J Sekelsky 1
PMCID: PMC1470841  PMID: 15166153

Abstract

Drosophila mei-9 is essential for several DNA repair and recombination pathways, including nucleotide excision repair (NER), interstrand crosslink repair, and meiotic recombination. To better understand the role of MEI-9 in these processes, we characterized 10 unique mutant alleles of mei-9. These include a P-element insertion that disrupts repair functions but not the meiotic function; three nonsense mutations, one of which has nearly wild-type levels of protein; three missense mutations, one of which disrupts the meiotic function but not repair functions; two small in-frame deletions; and one frameshift.

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Selected References

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