Abstract
Genomic evidence for colocalization of functionally related genes on eukaryote chromosomes is mounting. Here we show that a statistically significant fraction of yeast genes coding for subunits of stable complexes are located within 10-30 kb of each other. Clustering of genes encoding subunits of complexes may ensure better coregulation and maintain the right stoichiometry of complexes upon duplication of chromosomal segments.
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Selected References
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- Birchler J. A., Bhadra U., Bhadra M. P., Auger D. L. Dosage-dependent gene regulation in multicellular eukaryotes: implications for dosage compensation, aneuploid syndromes, and quantitative traits. Dev Biol. 2001 Jun 15;234(2):275–288. doi: 10.1006/dbio.2001.0262. [DOI] [PubMed] [Google Scholar]
- Blumenthal T., Spieth J. Gene structure and organization in Caenorhabditis elegans. Curr Opin Genet Dev. 1996 Dec;6(6):692–698. doi: 10.1016/s0959-437x(96)80022-0. [DOI] [PubMed] [Google Scholar]
- Cohen B. A., Mitra R. D., Hughes J. D., Church G. M. A computational analysis of whole-genome expression data reveals chromosomal domains of gene expression. Nat Genet. 2000 Oct;26(2):183–186. doi: 10.1038/79896. [DOI] [PubMed] [Google Scholar]
- Ge H., Liu Z., Church G. M., Vidal M. Correlation between transcriptome and interactome mapping data from Saccharomyces cerevisiae. Nat Genet. 2001 Dec;29(4):482–486. doi: 10.1038/ng776. [DOI] [PubMed] [Google Scholar]
- Jansen Ronald, Greenbaum Dov, Gerstein Mark. Relating whole-genome expression data with protein-protein interactions. Genome Res. 2002 Jan;12(1):37–46. doi: 10.1101/gr.205602. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Langkjaer Rikke B., Cliften Paul F., Johnston Mark, Piskur Jure. Yeast genome duplication was followed by asynchronous differentiation of duplicated genes. Nature. 2003 Feb 20;421(6925):848–852. doi: 10.1038/nature01419. [DOI] [PubMed] [Google Scholar]
- Lee Jennifer M., Sonnhammer Erik L. L. Genomic gene clustering analysis of pathways in eukaryotes. Genome Res. 2003 Apr 14;13(5):875–882. doi: 10.1101/gr.737703. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Mewes H. W., Frishman D., Güldener U., Mannhaupt G., Mayer K., Mokrejs M., Morgenstern B., Münsterkötter M., Rudd S., Weil B. MIPS: a database for genomes and protein sequences. Nucleic Acids Res. 2002 Jan 1;30(1):31–34. doi: 10.1093/nar/30.1.31. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Papp Balázs, Pál Csaba, Hurst Laurence D. Dosage sensitivity and the evolution of gene families in yeast. Nature. 2003 Jul 10;424(6945):194–197. doi: 10.1038/nature01771. [DOI] [PubMed] [Google Scholar]
- Pál Csaba, Hurst Laurence D. Evidence for co-evolution of gene order and recombination rate. Nat Genet. 2003 Feb 10;33(3):392–395. doi: 10.1038/ng1111. [DOI] [PubMed] [Google Scholar]
- Seoighe C., Federspiel N., Jones T., Hansen N., Bivolarovic V., Surzycki R., Tamse R., Komp C., Huizar L., Davis R. W. Prevalence of small inversions in yeast gene order evolution. Proc Natl Acad Sci U S A. 2000 Dec 19;97(26):14433–14437. doi: 10.1073/pnas.240462997. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Teichmann Sarah A. The constraints protein-protein interactions place on sequence divergence. J Mol Biol. 2002 Nov 29;324(3):399–407. doi: 10.1016/s0022-2836(02)01144-0. [DOI] [PubMed] [Google Scholar]
- Veitia Reiner A. Exploring the etiology of haploinsufficiency. Bioessays. 2002 Feb;24(2):175–184. doi: 10.1002/bies.10023. [DOI] [PubMed] [Google Scholar]