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. 1998 Jan 1;26(1):55–59. doi: 10.1093/nar/26.1.55

RegulonDB: a database on transcriptional regulation in Escherichia coli.

A M Huerta 1, H Salgado 1, D Thieffry 1, J Collado-Vides 1
PMCID: PMC147189  PMID: 9399800

Abstract

RegulonDB is a DataBase that integrates biological knowledge of the mechanisms that regulate the transcription initiation in Escherichia coli , as well as knowledge on the organization of the genes and regulatory signals into operons in the chromosome. The operon is the basic structure used in RegulonDB to describe the elements and properties of transcriptional regulation. The current version contains information around some 500 regulation mechanisms, essentially for sigma 70 promoters.

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Selected References

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  1. Blattner F. R., Plunkett G., 3rd, Bloch C. A., Perna N. T., Burland V., Riley M., Collado-Vides J., Glasner J. D., Rode C. K., Mayhew G. F. The complete genome sequence of Escherichia coli K-12. Science. 1997 Sep 5;277(5331):1453–1462. doi: 10.1126/science.277.5331.1453. [DOI] [PubMed] [Google Scholar]
  2. Collado-Vides J., Magasanik B., Gralla J. D. Control site location and transcriptional regulation in Escherichia coli. Microbiol Rev. 1991 Sep;55(3):371–394. doi: 10.1128/mr.55.3.371-394.1991. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. JACOB F., MONOD J. Genetic regulatory mechanisms in the synthesis of proteins. J Mol Biol. 1961 Jun;3:318–356. doi: 10.1016/s0022-2836(61)80072-7. [DOI] [PubMed] [Google Scholar]
  4. Karp P. D., Riley M., Paley S. M., Pelligrini-Toole A. EcoCyc: an encyclopedia of Escherichia coli genes and metabolism. Nucleic Acids Res. 1996 Jan 1;24(1):32–39. doi: 10.1093/nar/24.1.32. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Lisser S., Margalit H. Compilation of E. coli mRNA promoter sequences. Nucleic Acids Res. 1993 Apr 11;21(7):1507–1516. doi: 10.1093/nar/21.7.1507. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Rouxel T., Danchin A., Henaut A. METALGEN.DB: metabolism linked to the genome of Escherichia coli, a graphics-oriented database. Comput Appl Biosci. 1993 Jun;9(3):315–324. doi: 10.1093/bioinformatics/9.3.315. [DOI] [PubMed] [Google Scholar]
  7. Wingender E., Dietze P., Karas H., Knüppel R. TRANSFAC: a database on transcription factors and their DNA binding sites. Nucleic Acids Res. 1996 Jan 1;24(1):238–241. doi: 10.1093/nar/24.1.238. [DOI] [PMC free article] [PubMed] [Google Scholar]

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