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. 1998 Jan 1;26(1):297–303. doi: 10.1093/nar/26.1.297

IMGT, the International ImMunoGeneTics database.

M P Lefranc 1, V Giudicelli 1, C Busin 1, J Bodmer 1, W Müller 1, R Bontrop 1, M Lemaitre 1, A Malik 1, D Chaume 1
PMCID: PMC147225  PMID: 9399859

Abstract

IMGT, the international ImMunoGeneTics database, is an integrated database specialising in Immunoglobulins (Ig), T cell Receptors (TcR) and Major Histocompatibility Complex (MHC) of all vertebrate species, created by Marie-Paule Lefranc, CNRS, Montpellier II University, Montpellier, France (lefranc@ligm.crbm.cnrs-mop.fr). IMGT includes three databases: LIGM-DB (for Ig and TcR), MHC/HLA-DB and PRIMER-DB (the last two in development). IMGT comprises expertly annotated sequences and alignment tables. LIGM-DB contains more than 23 000 Immunoglobulin and T cell Receptor sequences from 78 species. MHC/HLA-DB contains Class I and Class II Human Leucocyte Antigen alignment tables. An IMGT tool, DNAPLOT, developed for Ig, TcR and MHC sequence alignments, is also available. IMGT works in close collaboration with the EMBL database. IMGT goals are to establish a common data access to all immunogenetics data, including nucleotide and protein sequences, oligonucleotide primers, gene maps and other genetic data of Ig, TcR and MHC molecules, and to provide a graphical user friendly data access. IMGT has important implications in medical research (repertoire in autoimmune diseases, AIDS, leukemias, lymphomas), therapeutical approaches (antibody engineering), genome diversity and genome evolution studies. IMGT is freely available at http://imgt.cnusc.fr:8104

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Selected References

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  1. Bairoch A., Apweiler R. The SWISS-PROT protein sequence data bank and its supplement TrEMBL in 1998. Nucleic Acids Res. 1998 Jan 1;26(1):38–42. doi: 10.1093/nar/26.1.38. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Chothia C., Lesk A. M. Canonical structures for the hypervariable regions of immunoglobulins. J Mol Biol. 1987 Aug 20;196(4):901–917. doi: 10.1016/0022-2836(87)90412-8. [DOI] [PubMed] [Google Scholar]
  3. Giudicelli V., Chaume D., Bodmer J., Müller W., Busin C., Marsh S., Bontrop R., Marc L., Malik A., Lefranc M. P. IMGT, the international ImMunoGeneTics database. Nucleic Acids Res. 1997 Jan 1;25(1):206–211. doi: 10.1093/nar/25.1.206. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Lefranc M. P. Organization of the human T-cell receptor genes. Eur Cytokine Netw. 1990 Aug-Sep;1(3):121–130. [PubMed] [Google Scholar]
  5. Lefranc M. P. Unique database numbering system for immunogenetic analysis. Immunol Today. 1997 Nov;18(11):509–509. doi: 10.1016/s0167-5699(97)01163-8. [DOI] [PubMed] [Google Scholar]
  6. Satow Y., Cohen G. H., Padlan E. A., Davies D. R. Phosphocholine binding immunoglobulin Fab McPC603. An X-ray diffraction study at 2.7 A. J Mol Biol. 1986 Aug 20;190(4):593–604. doi: 10.1016/0022-2836(86)90245-7. [DOI] [PubMed] [Google Scholar]
  7. Stoesser G., Moseley M. A., Sleep J., McGowran M., Garcia-Pastor M., Sterk P. The EMBL nucleotide sequence database. Nucleic Acids Res. 1998 Jan 1;26(1):8–15. doi: 10.1093/nar/26.1.8. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Tateno Y., Fukami-Kobayashi K., Miyazaki S., Sugawara H., Gojobori T. DNA Data Bank of Japan at work on genome sequence data. Nucleic Acids Res. 1998 Jan 1;26(1):16–20. doi: 10.1093/nar/26.1.16. [DOI] [PMC free article] [PubMed] [Google Scholar]

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