Abstract
We have continued to develop MITOMAP (http://www.gen.emory. edu/MITOMAP ), a comprehensive database for the human mitochondrial DNA (mtDNA). MITOMAP uses the mtDNA sequence as the unifying element for bringing together information on mitochondrial genome structure and function, pathogenic mutations and their clinical characteristics, population associated variation, and gene-gene interactions. Over the past year we have increased the degree of interlinking of MITOMAP information available on the web page, by using our generalized information management system, GENOME. As increasingly larger regions of the human genome are sequenced and characterized, the need for integrating such information is growing. Consequently, MITOMAP and GENOME provide a valuable reference for the mitochondrial biologist, in addition to being a model for the development of comprehensive, information storage and retrieval systems for other components of the human genome. This paper documents the changes to MITOMAP which have been implemented over the past year.
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Selected References
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- Anderson S., Bankier A. T., Barrell B. G., de Bruijn M. H., Coulson A. R., Drouin J., Eperon I. C., Nierlich D. P., Roe B. A., Sanger F. Sequence and organization of the human mitochondrial genome. Nature. 1981 Apr 9;290(5806):457–465. doi: 10.1038/290457a0. [DOI] [PubMed] [Google Scholar]
- Fasman K. H., Letovsky S. I., Cottingham R. W., Kingsbury D. T. Improvements to the GDB Human Genome Data Base. Nucleic Acids Res. 1996 Jan 1;24(1):57–63. doi: 10.1093/nar/24.1.57. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Kogelnik A. M., Lott M. T., Brown M. D., Navathe S. B., Wallace D. C. MITOMAP: a human mitochondrial genome database. Nucleic Acids Res. 1996 Jan 1;24(1):177–179. doi: 10.1093/nar/24.1.177. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Pearson P., Francomano C., Foster P., Bocchini C., Li P., McKusick V. The status of online Mendelian inheritance in man (OMIM) medio 1994. Nucleic Acids Res. 1994 Sep;22(17):3470–3473. doi: 10.1093/nar/22.17.3470. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Wallace D. C. 1994 William Allan Award Address. Mitochondrial DNA variation in human evolution, degenerative disease, and aging. Am J Hum Genet. 1995 Aug;57(2):201–223. [PMC free article] [PubMed] [Google Scholar]
- Wallace D. C. Diseases of the mitochondrial DNA. Annu Rev Biochem. 1992;61:1175–1212. doi: 10.1146/annurev.bi.61.070192.005523. [DOI] [PubMed] [Google Scholar]