Abstract
An integral representation for the membrane admittance in terms of its known current response to a voltage step function is presented. It is demonstrated that the frequency-dependent terms in the contribution to the membrane admittance by the ion-selective conductance of the nerve membrane are proportional to the static conductances. The additional information contained in the real and imaginary parts of the membrane admittance should allow the parameters of the ion conductance to be determined. Eventually, these measurements should also give information about the electric dipole displacement currents of the conductance systems themselves, and about the metabolically supported active ion transport currents that maintain the ion concentration gradients.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- CHANDLER W. K., FITZHUGH R., COLE K. S. Theoretical stability properties of a space-clamped axon. Biophys J. 1962 Mar;2:105–127. doi: 10.1016/s0006-3495(62)86844-1. [DOI] [PMC free article] [PubMed] [Google Scholar]
- DeFelice L. J., Wanke E., Conti F. Potassium and sodium current noise from squid axon membranes. Fed Proc. 1975 Apr;34(5):1338–1342. [PubMed] [Google Scholar]
- Fishman H. M., Poussart D. J., Moore L. E., Siebenga E. K+ conduction description from the low frequency impedance and admittance of squid axon. J Membr Biol. 1977 Apr 22;32(3-4):255–290. doi: 10.1007/BF01905222. [DOI] [PubMed] [Google Scholar]
- Mauro A., Conti F., Dodge F., Schor R. Subthreshold behavior and phenomenological impedance of the squid giant axon. J Gen Physiol. 1970 Apr;55(4):497–523. doi: 10.1085/jgp.55.4.497. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Strandberg M. W. Action potential in the giant axon of Loligo: a physical model. J Theor Biol. 1976 May 7;58(1):33–53. doi: 10.1016/0022-5193(76)90137-5. [DOI] [PubMed] [Google Scholar]
- Strandberg M. W. Transient polarization currents in the squid giant axon. Biophys J. 1977 Sep;19(3):275–284. doi: 10.1016/S0006-3495(77)85587-2. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Takashima S. Membrane capacity of squid giant axon during hyper- and depolarizations. J Membr Biol. 1976 Jun 9;27(1-2):21–39. doi: 10.1007/BF01869127. [DOI] [PubMed] [Google Scholar]
- Takashima S., Schwan H. P. Passive electrical properties of squid axon membrane. J Membr Biol. 1974;17(1):51–68. doi: 10.1007/BF01870172. [DOI] [PubMed] [Google Scholar]