Abstract
We have demonstrated that the pyrolysis products of amino acids and proteins in model systems are mutagenic. The mutagenic principles in the pyrolyzates of amino acids have been isolated and identified by Sugimura et al. We have isolated and identified amino-alpha-carbolines from pyrolyzed soybean globulin as mutagens. The yield of mutagens by the heating of food constituents is changed by the heating method. Effects of heating methods on the yield of amino-alpha-carbolines were studied in a series of experiments, and the results are shown in this paper. Additionally, it has been shown that by the heating of creatine-sugar mixtures imidazoquinoline or quinoxaline mutagens are formed.
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Selected References
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- Ashoor S. H., Dietrich R. A., Chu F. S., Pariza M. W. Proline enhances mutagen formation in ground beef during frying. Life Sci. 1980 May 26;26(21):1801–1805. doi: 10.1016/0024-3205(80)90581-0. [DOI] [PubMed] [Google Scholar]
- Matsumoto T., Yoshida D., Mizusaki S., Okamoto H. Mutagenic activity of amino acid pyrolyzates in Salmonella typhimurium TA 98. Mutat Res. 1977 Jul;48(3-4):279–286. doi: 10.1016/0027-5107(77)90170-1. [DOI] [PubMed] [Google Scholar]
- Matsumoto T., Yoshida D., Mizusaki S., Okamoto H. Mutagenicities of the pyrolyzates of peptides and proteins. Mutat Res. 1978 Jan;56(3):281–288. doi: 10.1016/0027-5107(78)90194-x. [DOI] [PubMed] [Google Scholar]
- Matsumoto T., Yoshida D., Tomita H. Determination of mutagens, amino-alpha-carbolines in grilled foods and cigarette smoke condensate. Cancer Lett. 1981 Mar;12(1-2):105–110. doi: 10.1016/0304-3835(81)90045-8. [DOI] [PubMed] [Google Scholar]
- Sugimura T., Sato S. Mutagens-carcinogens in foods. Cancer Res. 1983 May;43(5 Suppl):2415s–2421s. [PubMed] [Google Scholar]
- Yoshida D., Matsumoto T., Yoshimura R., Matsuzaki T. Mutagenicity of amino-alpha-carbolines in pyrolysis products of soybean globulin. Biochem Biophys Res Commun. 1978 Aug 14;83(3):915–920. doi: 10.1016/0006-291x(78)91482-1. [DOI] [PubMed] [Google Scholar]
- Yoshida D., Okamoto H. Formation of mutagens by heating creatine and glucose. Biochem Biophys Res Commun. 1980 Sep 30;96(2):844–847. doi: 10.1016/0006-291x(80)91432-1. [DOI] [PubMed] [Google Scholar]