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. 1987 Nov;75:25–27. doi: 10.1289/ehp.877525

Estrogens and development.

J A McLachlan 1, R R Newbold 1
PMCID: PMC1474430  PMID: 3319561

Abstract

The normal development of the genital organs of mammals, including humans, is under hormonal control. A role for the female sex hormone estrogen in this process is still unclear. However, exposure of experimental animals or humans to the potent exogenous estrogen, diethylstilbestrol (DES), results in persistent differentiation effects. Since many chemicals in the environment are weakly estrogenic, the possibility of hormonally altered differentiation must be considered.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Comas A. P. Precocious sexual development in Puerto Rico. Lancet. 1982 Jun 5;1(8284):1299–1300. doi: 10.1016/s0140-6736(82)92857-4. [DOI] [PubMed] [Google Scholar]
  2. DeCherney A. H., Cholst I., Naftolin F. Structure and function of the fallopian tubes following exposure to diethylstilbestrol (DES) during gestation. Fertil Steril. 1981 Dec;36(6):741–745. doi: 10.1016/s0015-0282(16)45919-4. [DOI] [PubMed] [Google Scholar]
  3. Haney A. F., Hammond C. B., Soules M. R., Creasman W. T. Diethylstilbestrol-induced upper genital tract abnormalities. Fertil Steril. 1979 Feb;31(2):142–146. [PubMed] [Google Scholar]
  4. Haney A. F., Newbold R. R., Fetter B. F., McLachlan J. A. Paraovarian cysts associated with prenatal diethylstilbestrol exposure. Comparison of the human with a mouse model. Am J Pathol. 1986 Sep;124(3):405–411. [PMC free article] [PubMed] [Google Scholar]
  5. Herbst A. L., Poskanzer D. C., Robboy S. J., Friedlander L., Scully R. E. Prenatal exposure to stilbestrol. A prospective comparison of exposed female offspring with unexposed controls. N Engl J Med. 1975 Feb 13;292(7):334–339. doi: 10.1056/NEJM197502132920704. [DOI] [PubMed] [Google Scholar]
  6. Korach K. S., Metzler M., McLachlan J. A. Estrogenic activity in vivo and in vitro of some diethylstilbestrol metabolites and analogs. Proc Natl Acad Sci U S A. 1978 Jan;75(1):468–471. doi: 10.1073/pnas.75.1.468. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Leopold A. S., Erwin M., Oh J., Browning B. Phytoestrogens: adverse effects on reproduction in California quail. Science. 1976 Jan 9;191(4222):98–100. doi: 10.1126/science.1246602. [DOI] [PubMed] [Google Scholar]
  8. McLachlan J. A., Newbold R. R., Bullock B. C. Long-term effects on the female mouse genital tract associated with prenatal exposure to diethylstilbestrol. Cancer Res. 1980 Nov;40(11):3988–3999. [PubMed] [Google Scholar]
  9. Newbold R. R., Carter D. B., Harris S. E., McLachlan J. A. Molecular differentiation of the mouse genital tract: altered protein synthesis following prenatal exposure to diethylstilbestrol. Biol Reprod. 1984 Mar;30(2):459–470. doi: 10.1095/biolreprod30.2.459. [DOI] [PubMed] [Google Scholar]
  10. Newbold R. R., McLachlan J. A. Vaginal adenosis and adenocarcinoma in mice exposed prenatally or neonatally to diethylstilbestrol. Cancer Res. 1982 May;42(5):2003–2011. [PubMed] [Google Scholar]
  11. Newbold R. R., Tyrey S., Haney A. F., McLachlan J. A. Developmentally arrested oviduct: a structural and functional defect in mice following prenatal exposure to diethylstilbestrol. Teratology. 1983 Jun;27(3):417–426. doi: 10.1002/tera.1420270316. [DOI] [PubMed] [Google Scholar]
  12. Rawitch A. B., Schultz G. S., Ebner K. E., Vardaris R. M. Competition of delta 9-tetrahydrocannabinol with estrogen in rat uterine estrogen receptor binding. Science. 1977 Sep 16;197(4309):1189–1191. doi: 10.1126/science.897662. [DOI] [PubMed] [Google Scholar]
  13. Schneider S. L., Alks V., Morreal C. E., Sinha D. K., Dao T. L. Estrogenic properties of 3,9-dihydroxybenz[a]anthracene, a potential metabolite of benz[a]anthracene. J Natl Cancer Inst. 1976 Dec;57(6):1351–1354. [PubMed] [Google Scholar]
  14. Setchell K. D., Gosselin S. J., Welsh M. B., Johnston J. O., Balistreri W. F., Kramer L. W., Dresser B. L., Tarr M. J. Dietary estrogens--a probable cause of infertility and liver disease in captive cheetahs. Gastroenterology. 1987 Aug;93(2):225–233. doi: 10.1016/0016-5085(87)91006-7. [DOI] [PubMed] [Google Scholar]
  15. Sáenz C. A., Toro-Solá M., Conde L., Bayonet-Rivera N. P. Premature thelarche and ovarian cyst probably secondary to estrogen contamination. Bol Asoc Med P R. 1982 Feb;74(2):16–19. [PubMed] [Google Scholar]

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