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. 1988 Apr;77:23–28. doi: 10.1289/ehp.887723

Prostatic carcinogenesis evoked by cellular interaction.

L W Chung 1, S M Chang 1, C Bell 1, H Zhau 1, J Y Ro 1, A C von Eschenbach 1
PMCID: PMC1474533  PMID: 3383820

Abstract

Inoculation of tumorigenic prostatic stroma and nontumorigenic prostatic epithelia into the subcutaneous space of syngeneic rats induced the development of carcinosarcoma. The induced tumors, which were composed of a mixture of adenocarcinoma and fibrosarcoma, were androgen responsive. This model offers a novel mechanism for prostatic carcinogenesis in which prostatic fibroblasts determine epithelial growth, androgen responsiveness, and tumorigenicity. Our results emphasize the potential importance of an epigenetic pathway in prostatic carcinogenesis.

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Selected References

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