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. 1988 Jun;78:71–76. doi: 10.1289/ehp.887871

Evidence for effects of chronic lead exposure on blood pressure in experimental animals: an overview.

W Victery 1
PMCID: PMC1474614  PMID: 3060353

Abstract

Information obtained in a number of experimental studies conducted over the last 40 years on the effects of lead on blood pressure is reviewed. Differences in animal species, age at beginning of exposure, level of lead exposure, indices of lead burden, and blood pressure effects of each study are reported. In several of the high-dose experiments, hypertension was observed, but nephrotoxicity of lead may have contributed to its development. Moreover, in other high-dose experiments, no hypertension was observed, and in at least one experiment, the evidence suggested that lead could reduce an elevated blood pressure. In contrast, the lower dose experiments consistently demonstrated a hypertensive effect. Overall, the data suggest a biphasic dose response. Establishment of an appropriate animal model to study blood pressure effects of lead will require careful assessment of dietary interactions with lead, unstressed blood pressure monitoring with standardized techniques, and documentation of biologically effective lead burden. Future research should examine lead exposure at more environmentally appropriate levels in order to determine the validity of associating this pollutant with blood pressure effects in the human population.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Boscolo P., Carmignani M. Neurohumoral blood pressure regulation in lead exposure. Environ Health Perspect. 1988 Jun;78:101–106. doi: 10.1289/ehp.8878101. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. COTTIER P., KUNZ H. A., ZOLLINGER H. U. Experimenteller Beitrag zur Frage der Bleihypertonie. Helv Med Acta. 1953 Nov;20(4-5):443–449. [PubMed] [Google Scholar]
  3. Chai S. S., Webb R. C. Effects of lead on vascular reactivity. Environ Health Perspect. 1988 Jun;78:85–89. doi: 10.1289/ehp.887885. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Evis M. J., Dhaliwal K., Kane K. A., Moore M. R., Parratt J. R. The effects of chronic lead treatment and hypertension on the severity of cardiac arrhythmias induced by coronary artery occlusion or by noradrenaline in anaesthetised rats. Arch Toxicol. 1987 Feb;59(5):336–340. doi: 10.1007/BF00295086. [DOI] [PubMed] [Google Scholar]
  5. Iannaccone A., Carmignani M., Boscolo P. Neurogenic and humoral mechanisms in arterial hypertension of chronically lead-exposed rats. Med Lav. 1981 Jan-Feb;72(1):13–21. [PubMed] [Google Scholar]
  6. Kopp S. J., Barron J. T., Tow J. P. Cardiovascular actions of lead and relationship to hypertension: a review. Environ Health Perspect. 1988 Jun;78:91–99. doi: 10.1289/ehp.887891. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. PARDOE A. U. Renal function in lead poisoning. Br J Pharmacol Chemother. 1952 Sep;7(3):349–357. doi: 10.1111/j.1476-5381.1952.tb00703.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Padilla F., Shapiro A. P., Jensen W. N. Effect of chronic lead intoxication on blood pressure in the rat. Am J Med Sci. 1969 Nov;258(5):359–365. doi: 10.1097/00000441-196911000-00007. [DOI] [PubMed] [Google Scholar]
  9. Revis N. W., Zinsmeister A. R., Bull R. Atherosclerosis and hypertension induction by lead and cadmium ions: an effect prevented by calcium ion. Proc Natl Acad Sci U S A. 1981 Oct;78(10):6494–6498. doi: 10.1073/pnas.78.10.6494. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Sharp D. S., Becker C. E., Smith A. H. Chronic low-level lead exposure. Its role in the pathogenesis of hypertension. Med Toxicol. 1987 May-Jun;2(3):210–232. doi: 10.1007/BF03259865. [DOI] [PubMed] [Google Scholar]
  11. Vander A. J. Chronic effects of lead on the renin-angiotensin system. Environ Health Perspect. 1988 Jun;78:77–83. doi: 10.1289/ehp.887877. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Victery W., Vander A. J., Markel H., Katzman L., Shulak J. M., Germain C. Lead exposure, begun in utero, decreases renin and angiotensin II in adult rats. Proc Soc Exp Biol Med. 1982 May;170(1):63–67. doi: 10.3181/00379727-170-41398. [DOI] [PubMed] [Google Scholar]
  13. Victery W., Vander A. J., Shulak J. M., Schoeps P., Julius S. Lead, hypertension, and the renin-angiotensin system in rats. J Lab Clin Med. 1982 Mar;99(3):354–362. [PubMed] [Google Scholar]

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