Skip to main content
PMC home page
Environmental Health Perspectives logoLink to Environmental Health Perspectives
. 1972 Oct;2:55–66. doi: 10.1289/ehp.720255

Some studies and comments on hepatic and extrahepatic microsomal toxication-detoxication systems. A limited discussion of some of the heterogeneities of these systems and of their responses to stimulation of enzyme "induction".

J R Fouts
PMCID: PMC1474901  PMID: 4404490

Full text

PDF
55

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Alvares A. P., Schilling G., Levin W. Species differences in the induction of microsomal hemoproteins and 3,4-benzpyrene hydroxylase by phenobarbital and 3-methylcholanthrene. J Pharmacol Exp Ther. 1970 Oct;175(1):4–11. [PubMed] [Google Scholar]
  2. Cram R. L., Fouts J. R. The influence of DDT and gamma-chlordane on the metabolism of hexobarbital and zoxazolamine in 2 mouse strains. Biochem Pharmacol. 1967 Jun;16(6):1001–1006. doi: 10.1016/0006-2952(67)90272-9. [DOI] [PubMed] [Google Scholar]
  3. Dallman P. R., Dallner G., Bergstrand A., Ernster L. Heterogeneous distribution of enzymes in submicrosomal membrane fragments. J Cell Biol. 1969 May;41(2):357–377. doi: 10.1083/jcb.41.2.357. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Eling T. E., Harbison R. D., Becker B. A., Fouts J. R. Diphenylhydantoin effect on neonatal and adult rat hepatic drug metabolism. J Pharmacol Exp Ther. 1970 Jan;171(1):127–134. [PubMed] [Google Scholar]
  5. Eling T. E., Harbison R. D., Becker B. A., Fouts J. R. Kinetic changes in microsomal drug metabolism with age and diphenylhydantoin treatment. Eur J Pharmacol. 1970 Jul 1;11(1):101–108. doi: 10.1016/0014-2999(70)90260-8. [DOI] [PubMed] [Google Scholar]
  6. FOUTS J. R., ADAMSON R. H. Drug metabolism in the newborn rabbit. Science. 1959 Apr 3;129(3353):897–898. doi: 10.1126/science.129.3353.897. [DOI] [PubMed] [Google Scholar]
  7. FOUTS J. R., HART L. G. HEPATIC DRUG METABOLISM DURING THE PERINATAL PERIOD. Ann N Y Acad Sci. 1965 Mar 12;123:245–251. doi: 10.1111/j.1749-6632.1965.tb12263.x. [DOI] [PubMed] [Google Scholar]
  8. FOUTS J. R. The metabolism of drugs by subfractions of hepatic microsomes. Biochem Biophys Res Commun. 1961 Dec 20;6:373–378. doi: 10.1016/0006-291x(61)90148-6. [DOI] [PubMed] [Google Scholar]
  9. Fouts J. R., Pohl R. J. Further studies on the effects of metal ions on rat liver microsomal reduced nicotinamide adenine dinucleotide phosphate-cytochrome P-450 reductase. J Pharmacol Exp Ther. 1971 Oct;179(1):91–100. [PubMed] [Google Scholar]
  10. Fouts J. R., Rogers L. A., Gram T. E. The metabolism of drugs by hepatic microsomal enzymes. Studies on intramicrosomal distribution of enzymes and relationships between enzyme activity and structure of the hepatic endoplasmic reticulum. Exp Mol Pathol. 1966 Oct;5(5):475–490. doi: 10.1016/0014-4800(66)90027-x. [DOI] [PubMed] [Google Scholar]
  11. Gielen J. E., Goujon F. M., Nebert D. W. Genetic regulation of aryl hydrocarbon hydroxylase induction. II. Simple Mendelian expression in mouse tissues in vivo. J Biol Chem. 1972 Feb 25;247(4):1125–1137. [PubMed] [Google Scholar]
  12. Gigon P. L., Gram T. E., Gillette J. R. Studies on the rate of reduction of hepatic microsomal cytochrome P-450 by reduced nicotinamide adenine dinucleotide phosphate: effect of drug substrates. Mol Pharmacol. 1969 Mar;5(2):109–122. [PubMed] [Google Scholar]
  13. Glaumann H., Dallner G. Subfractionation of smooth microsomes from rat liver. J Cell Biol. 1970 Oct;47(1):34–48. doi: 10.1083/jcb.47.1.34. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Glazer R. I., Schenkman J. B., Sartorelli A. C. Immunochemical studies on the role of reduced nicotinamide adenine dinucleotide phosphate-cytochrome c (P-450) reductase in drug oxidation. Mol Pharmacol. 1971 Nov;7(6):683–688. [PubMed] [Google Scholar]
  15. Gram T. E., Fouts J. R. Further studies on the metabolism of drugs by subfractions of hepatic microsomes. 3. Effects of the NADPH-generating system. J Pharmacol Exp Ther. 1967 Nov;158(2):317–322. [PubMed] [Google Scholar]
  16. Gram T. E., Hansen A. R., Fouts J. R. The submicrosomal distribution of hepatic uridine diphosphate glucuronyltransferases in the rabbit. Biochem J. 1968 Feb;106(3):587–591. doi: 10.1042/bj1060587. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Gram T. E., Rogers L. A., Fouts J. R. Effect of pretreatment of rabbits with phenobarbital or 3-methylcholanthrene on the distribution of drug-metabolizing enzyme activity in subfractions of hepatic microsomes. J Pharmacol Exp Ther. 1967 Aug;157(2):435–445. [PubMed] [Google Scholar]
  18. Gram T. E., Rogers L. A., Fouts J. R. Further studies on the metabolism of drugs by subfractions of hepatic microsomes. J Pharmacol Exp Ther. 1967 Mar;155(3):479–493. [PubMed] [Google Scholar]
  19. HART L. G., ADAMSON R. H., DIXON R. L., FOUTS J. R. Stimulation of hepatic microsomal drug metabolism in the newborn and fetal rabbit. J Pharmacol Exp Ther. 1962 Jul;137:103–106. [PubMed] [Google Scholar]
  20. HART L. G., FOUTS J. R. FURTHER STUDIES ON THE STIMULATION OF HEPATIC MICROSOMAL DRUG METABOLIZING ENZYMES BY DDT AND ITS ANALOGS. Naunyn Schmiedebergs Arch Exp Pathol Pharmakol. 1965 Jan 8;249:486–500. doi: 10.1007/BF00246555. [DOI] [PubMed] [Google Scholar]
  21. Hansen A. R., Fouts J. R. A comparison of the effects of benzypyrene administration on some hepatic microsomal mixed-function oxidases of rats and mice. Biochem Pharmacol. 1971 Nov;20(11):3125–3143. doi: 10.1016/0006-2952(71)90117-1. [DOI] [PubMed] [Google Scholar]
  22. Hansen A. R., Fouts J. R. Influence of 3,4-benzpyrene or gamma-chlordane on the rate of metabolism and acute toxicity of aminopyrine, hexobarbital, and zoxazolamine in the mouse. Toxicol Appl Pharmacol. 1968 Sep;13(2):212–219. doi: 10.1016/0041-008x(68)90095-1. [DOI] [PubMed] [Google Scholar]
  23. Juchau M. R., Gram T. E., Fouts J. R. Stimulation of hepatic microsomal drug-metabolizing enyme systems in primtes byDDT. Gastroenterology. 1966 Aug;51(2):213–218. [PubMed] [Google Scholar]
  24. Masters B. S., Baron J., Taylor W. E., Isaacson E. L., LoSpalluto J. Immunochemical studies on electron transport chains involving cytochrome P-450. I. Effects of antibodies to pig liver microsomal reduced triphosphopyridine nucleotide-cytochrome c reductase and the non-heme iron protein from bovine adrenocortical mitochondria. J Biol Chem. 1971 Jul 10;246(13):4143–4150. [PubMed] [Google Scholar]
  25. Nebert D. W., Goujon F. M., Gielen J. E. Aryl hydrocarbon hydroxylase induction by polycyclic hydrocarbons: simple autosomal dominant trait in the mouse. Nat New Biol. 1972 Mar 29;236(65):107–110. doi: 10.1038/newbio236107a0. [DOI] [PubMed] [Google Scholar]
  26. Oppelt W. W., Zange M., Ross W. E., Remmer H. Comparison of microsomal drug hydroxylation in lung and liver of various species. Res Commun Chem Pathol Pharmacol. 1970 Jan;1(1):43–56. [PubMed] [Google Scholar]
  27. Peters M. A., Fouts J. R. A study of some possible mechanisms by which magnesium activates hepatic microsomal drug metabolism in vitro. J Pharmacol Exp Ther. 1970 Jun;173(2):233–241. [PubMed] [Google Scholar]
  28. Rosenbloom P. M., Bass A. D. A lung perfusion preparation for the study of drug metabolism. J Appl Physiol. 1970 Jul;29(1):138–144. doi: 10.1152/jappl.1970.29.1.138. [DOI] [PubMed] [Google Scholar]

Articles from Environmental Health Perspectives are provided here courtesy of National Institute of Environmental Health Sciences

RESOURCES