Skip to main content
PMC home page
Environmental Health Perspectives logoLink to Environmental Health Perspectives
. 1973 Sep;5:211–219. doi: 10.1289/ehp.7305211

Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on drug metabolism and hepatic microsomes of rats and mice.

J B Greig, F De Matteis
PMCID: PMC1474983  PMID: 4752904

Full text

PDF
211

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ALDRIDGE W. N. Adenosine triphosphatase in the microsomal fraction from rat brain. Biochem J. 1962 Jun;83:527–533. doi: 10.1042/bj0830527. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Alvares A. P., Schilling G., Levin W., Kuntzman R. Studies on the induction of CO-binding pigments in liver microsomes by phenobarbital and 3-methylcholanthrene. Biochem Biophys Res Commun. 1967 Nov 30;29(4):521–526. doi: 10.1016/0006-291x(67)90515-3. [DOI] [PubMed] [Google Scholar]
  3. BRODIE B. B., BURNS J. J., MARK L. C., LIEF P. A., BERNSTEIN E., PAPPER E. M. The fate of pentobarbital in man and dog and a method for its estimation in biological material. J Pharmacol Exp Ther. 1953 Sep;109(1):26–34. [PubMed] [Google Scholar]
  4. BURNS J. J., YU T. F., BERGER L., GUTMAN A. B. Zoxazolamine: physiological disposition, uricosuric properties. Am J Med. 1958 Sep;25(3):401–408. doi: 10.1016/0002-9343(58)90079-2. [DOI] [PubMed] [Google Scholar]
  5. Bond E. J., De Matteis F. Biochemical changes in rat liver after administration of carbon disulphide, with particular reference to microsomal changes. Biochem Pharmacol. 1969 Oct;18(10):2531–2549. doi: 10.1016/0006-2952(69)90368-2. [DOI] [PubMed] [Google Scholar]
  6. Buu-Hoï N. P., Hien D. P., Saint-Ruf G., Servoin-Sidoine J. Propriétés cancéromimétiques de la tétrachloro-2,3,7,8 dibenzo-p-dioxine ("dioxine") C R Acad Sci Hebd Seances Acad Sci D. 1971 Mar 8;272(10):1447–1450. [PubMed] [Google Scholar]
  7. CONNEY A. H., DAVISON C., GASTEL R., BURNS J. J. Adaptive increases in drug-metabolizing enzymes induced by phenobarbital and other drugs. J Pharmacol Exp Ther. 1960 Sep;130:1–8. [PubMed] [Google Scholar]
  8. CONNEY A. H., MILLER E. C., MILLER J. A. The metabolism of methylated aminoazo dyes. V. Evidence for induction of enzyme synthesis in the rat by 3-methylcholanthrene. Cancer Res. 1956 Jun;16(5):450–459. [PubMed] [Google Scholar]
  9. CONNEY A. H., TROUSOF N., BURNS J. J. The metabolic fate of zoxazolamine (flexin) in man. J Pharmacol Exp Ther. 1960 Apr;128:333–339. [PubMed] [Google Scholar]
  10. COOPER J. R., BRODIE B. B. The enzymatic metabolism of hexobarbital (evipal). J Pharmacol Exp Ther. 1955 Aug;114(4):409–417. [PubMed] [Google Scholar]
  11. Chromý V., Babjuk J. S. Determination of barbiturates in biological fluids. Clin Chim Acta. 1972 Mar;37:547–548. doi: 10.1016/0009-8981(72)90486-x. [DOI] [PubMed] [Google Scholar]
  12. FARBER E. ETHIONINE CARCINOGENESIS. Adv Cancer Res. 1963;7:383–474. doi: 10.1016/s0065-230x(08)60986-0. [DOI] [PubMed] [Google Scholar]
  13. Greig J. B. Effect of 2,3,7,8-tetrachlorodibenzo-1,4-dioxin on drug metabolism in the rat. Biochem Pharmacol. 1972 Dec 1;21(23):3196–3198. doi: 10.1016/0006-2952(72)90149-9. [DOI] [PubMed] [Google Scholar]
  14. Greig J. B., Jones G., Butler W. H., Barnes J. M. Toxic effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin. Food Cosmet Toxicol. 1973 Aug;11(4):585–595. doi: 10.1016/s0015-6264(73)80329-3. [DOI] [PubMed] [Google Scholar]
  15. Hildebrandt A., Remmer H., Estabrook R. W. Cytochrome P-450 of liver microsomes--one pigment or many. Biochem Biophys Res Commun. 1968 Mar 27;30(6):607–612. doi: 10.1016/0006-291x(68)90555-x. [DOI] [PubMed] [Google Scholar]
  16. Imai Y., Sato R. Anomalous spectral interactions of reduced P-450 with ethyl isocyanide and other lipophilic ligands. J Biochem. 1967 Oct;62(4):464–473. doi: 10.1093/oxfordjournals.jbchem.a128690. [DOI] [PubMed] [Google Scholar]
  17. KATO R., CHIESARA E., VASSANELLI P. Factors influencing induction of hepatic microsomal drug-metabolizing enzymes. Biochem Pharmacol. 1962 Mar;11:211–220. doi: 10.1016/0006-2952(62)90076-x. [DOI] [PubMed] [Google Scholar]
  18. Kamath S. A., Rubin E. Interaction of calcium with microsomes: a modified method for the rapid isolation of rat liver microsomes. Biochem Biophys Res Commun. 1972 Oct 6;49(1):52–59. doi: 10.1016/0006-291x(72)90008-3. [DOI] [PubMed] [Google Scholar]
  19. Kato R., Takanaka A., Takayanaghi M. Substrate-induced spectral change of liver microsomes in phenobarbital and methylcholanthrene-treated male and female rats. J Biochem. 1970 Sep;68(3):395–413. doi: 10.1093/oxfordjournals.jbchem.a129369. [DOI] [PubMed] [Google Scholar]
  20. Lu A. Y., Coon M. J. Role of hemoprotein P-450 in fatty acid omega-hydroxylation in a soluble enzyme system from liver microsomes. J Biol Chem. 1968 Mar 25;243(6):1331–1332. [PubMed] [Google Scholar]
  21. Lu A. Y., Jacobson M., Levin W., West S. B., Kuntzman R. Reconstituted liver microsomal enzyme system that hydroxylates drugs, other foreign compounds, and endogenous substrates. IV. Hydroxylation of aniline. Arch Biochem Biophys. 1972 Nov;153(1):294–297. doi: 10.1016/0003-9861(72)90447-x. [DOI] [PubMed] [Google Scholar]
  22. Lu A. Y., Junk K. W., Coon M. J. Resolution of the cytochrome P-450-containing omega-hydroxylation system of liver microsomes into three components. J Biol Chem. 1969 Jul 10;244(13):3714–3721. [PubMed] [Google Scholar]
  23. Nebert D. W., Goujon F. M., Gielen J. E. Aryl hydrocarbon hydroxylase induction by polycyclic hydrocarbons: simple autosomal dominant trait in the mouse. Nat New Biol. 1972 Mar 29;236(65):107–110. doi: 10.1038/newbio236107a0. [DOI] [PubMed] [Google Scholar]
  24. OMURA T., SATO R. Fractional solubilization of haemoproteins and partial purification of carbon monoxide-binding cytochrome from liver microsomes. Biochim Biophys Acta. 1963 Apr 2;71:224–226. doi: 10.1016/0006-3002(63)91015-1. [DOI] [PubMed] [Google Scholar]
  25. Schenkman J. B., Greim H., Zange M., Remmer H. On the problem of possible other forms of cytochrome P450 in liver microsomes. Biochim Biophys Acta. 1969 Jan 7;171(1):23–31. doi: 10.1016/0005-2744(69)90102-8. [DOI] [PubMed] [Google Scholar]
  26. Schenkman J. B., Remmer H., Estabrook R. W. Spectral studies of drug interaction with hepatic microsomal cytochrome. Mol Pharmacol. 1967 Mar;3(2):113–123. [PubMed] [Google Scholar]
  27. Sladek N. E., Mannering G. J. Evidence for a new P-450 hemoprotein in hepatic microsomes from methylcholanthrene treated rats. Biochem Biophys Res Commun. 1966 Sep 8;24(5):668–674. doi: 10.1016/0006-291x(66)90376-7. [DOI] [PubMed] [Google Scholar]
  28. Wiebel F. J., Leutz J. C., Gelboin H. V. Aryl hydrocarbon (benzo ( ) pyrene) hydroxylase: inducible in extrahepatic tissues of mouse strains not inducible in liver. Arch Biochem Biophys. 1973 Jan;154(1):292–294. doi: 10.1016/0003-9861(73)90060-x. [DOI] [PubMed] [Google Scholar]

Articles from Environmental Health Perspectives are provided here courtesy of National Institute of Environmental Health Sciences

RESOURCES