Abstract
The detection of lead in fetal tissues by chemical analysis has long been accepted as prima facie evidence for the permeability of the placenta to this nonessential trace metal. However, only a few investigations, all on lower mammalian species, have contributed any direct experimental data bearing on this physiological process. Recent radioactive tracer and radioautographic studies on rodents have shown that lead crosses the placental membranes rapidly and in significant amounts even at relatively low maternal blood levels. While it is not possible to extrapolate directly the results of these experiments to humans because of differences in placental structure and other factors, the results do serve as a warning of the possible hazard to the human embryo and fetus of even low levels of lead in the maternal system.
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Selected References
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- Carpenter S. J., Ferm V. H., Gale T. F. Permeability of the golden hamster placenta to inorganic lead: radioautographic evidence. Experientia. 1973 Mar 15;29(3):311–313. doi: 10.1007/BF01926496. [DOI] [PubMed] [Google Scholar]
- Dalldorf G., Williams R. R. IMPAIRMENT OF REPRODUCTION IN RATS BY INGESTION OF LEAD. Science. 1945 Dec 28;102(2661):668–670. doi: 10.1126/science.102.2661.668. [DOI] [PubMed] [Google Scholar]
- Haas T., Wieck A. G., Schaller K. H., Mache K., Valentin H. Die usuelle Bleibelastung bei Neugeborenen und ihren Müttern. Zentralbl Bakteriol Orig B. 1972 Feb;155(4):341–349. [PubMed] [Google Scholar]
- Harris P., Holley M. R. Lead levels in cord blood. Pediatrics. 1972 Apr;49(4):606–608. [PubMed] [Google Scholar]
- McClain R. M., Becker B. A. Effects of organolead compounds on rat embryonic and fetal development. Toxicol Appl Pharmacol. 1972 Feb;21(2):265–274. doi: 10.1016/0041-008x(72)90070-1. [DOI] [PubMed] [Google Scholar]
- Scanlon J. Umbilical cord blood lead concentration. Relationship to urban or suburban residency during gestation. Am J Dis Child. 1971 Apr;121(4):325–326. [PubMed] [Google Scholar]
- Tompsett S. L., Anderson A. B. The lead content of human tissues and excreta. Biochem J. 1935 Aug;29(8):1851–1864. doi: 10.1042/bj0291851. [DOI] [PMC free article] [PubMed] [Google Scholar]