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. 1976 Jun;15:27–38. doi: 10.1289/ehp.761527

The role of biotransformation in chemical-induced liver injury.

J R Mitchell, W R Snodgrass, J R Gillette
PMCID: PMC1475156  PMID: 1033831

Abstract

The role of drug metabolism in chemical-induced liver injury is reviewed. Parameters for studying the formation of chemically reactive metabolites are discussed and the factors that alter the formation and covalent binding of reactive metabolites are selectively emphasized. Some of the experimental work that led to these concepts is discussed, especially the chemical toxicology of the hepatic injury produced by acetaminophen, bromobenzene, furosemide, isoniazid and iproniazid.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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