Abstract
This paper describes our experience with the respiratory effects of TDI. Five respiratory reactions attributable to TDI are described with supporting evidence. The reactions are sensitization, irritation from overexposure, acute loss of ventilatory capacity, accelerated loss of pulmonary function and induction of a general asthmatic state. Evidence is presented that suggests a safe exposure level.
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- Adams W. G. Lung function of men engaged on the manufacture of tolylene diisocyanate (TDI). Proc R Soc Med. 1970 Apr;63(4):378–379. [PMC free article] [PubMed] [Google Scholar]
- BRUGSCH H. G., ELKINS H. B. Toluene di-isocyanate (TDI) toxicity. N Engl J Med. 1963 Feb 14;268:353–357. doi: 10.1056/NEJM196302142680705. [DOI] [PubMed] [Google Scholar]
- Burrows B., Earle R. H. Course and prognosis of chronic obstructive lung disease. A prospective study of 200 patients. N Engl J Med. 1969 Feb 20;280(8):397–404. doi: 10.1056/NEJM196902202800801. [DOI] [PubMed] [Google Scholar]
- FERRIS B. G., Jr, ANDERSON D. O., ZICKMANTEL R. PREDICTION VALUES FOR SCREENING TESTS OF PULMONARY FUNCTION. Am Rev Respir Dis. 1965 Feb;91:252–261. doi: 10.1164/arrd.1965.91.2.252. [DOI] [PubMed] [Google Scholar]
- FUCHS S., VALADE P. Etude clinique et expérimentale sur quelques cas d'intoxication par le desmodur T (diisocyanate de toluylène 1-2-4 et 1-2-6). Arch Mal Prof. 1951;12(2):191–196. [PubMed] [Google Scholar]
- GANDEVIA B. STUDIES OF VENTILATORY CAPACITY AND HISTAMINE RESPONSE DURING EXPOSURE TO ISOCYANATE VAPOUR IN POLYURETHANE FOAM MANUFACTURE. Br J Ind Med. 1963 Jul;20:204–209. doi: 10.1136/oem.20.3.204. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Higgins I. T., Gilson J. C., Ferris B. G., Jr, Waters M. E., Campbell H., Higgins M. W. Environmental epidemiology. IV. Chronic respiratory disease in an industrial town: a nine-year follow-up study. Preliminary report. Am J Public Health Nations Health. 1968 Sep;58(9):1667–1676. doi: 10.2105/ajph.58.9.1667. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Hill R. N. A controlled study of workers handling organic diisocyanates. Proc R Soc Med. 1970 Apr;63(4):375–375. [PMC free article] [PubMed] [Google Scholar]
- Howard P. Evolution of the ventilatory capacity in chronic bronchitis. Br Med J. 1967 Aug 12;3(5562):392–395. doi: 10.1136/bmj.3.5562.392. [DOI] [PMC free article] [PubMed] [Google Scholar]
- KORY R. C., CALLAHAN R., BOREN H. G., SYNER J. C. The Veterans Administration-Army cooperative study of pulmonary function. I. Clinical spirometry in normal men. Am J Med. 1961 Feb;30:243–258. doi: 10.1016/0002-9343(61)90096-1. [DOI] [PubMed] [Google Scholar]
- McKerrow C. B., Davies H. J., Parry Jones A. Symptoms and lung function following acute and chronic exposure to tolylene diisocyanate. Proc R Soc Med. 1970 Apr;63(4):376–378. [PMC free article] [PubMed] [Google Scholar]
- Morris J. F., Koski A., Johnson L. C. Spirometric standards for healthy nonsmoking adults. Am Rev Respir Dis. 1971 Jan;103(1):57–67. doi: 10.1164/arrd.1971.103.1.57. [DOI] [PubMed] [Google Scholar]
- Peters J. M., Murphy R. L., Pagnotto L. D., Van Ganse W. F. Acute respiratory effects in workers exposed to low levels of toluene diisocyanate (TDI). Arch Environ Health. 1968 May;16(5):642–647. doi: 10.1080/00039896.1968.10665121. [DOI] [PubMed] [Google Scholar]
- Rosenzweig D. Y., Arkins J. A., Schrock L. G. Ventilation studies on a normal population after a seven-year interval. Am Rev Respir Dis. 1966 Jul;94(1):74–78. doi: 10.1164/arrd.1966.94.1.74. [DOI] [PubMed] [Google Scholar]
- Wegman D. H., Pagnotto L. D., Fine L. J., Peters J. M. A dose-response relationship in TDI workers. J Occup Med. 1974 Apr;16(4):258–260. [PubMed] [Google Scholar]