Skip to main content
Environmental Health Perspectives logoLink to Environmental Health Perspectives
. 1977 Dec;21:45–47. doi: 10.1289/ehp.772145

Carcinogenicity studies on vinylidene chloride.

P L Viola, A Caputo
PMCID: PMC1475356  PMID: 612458

Abstract

Results of a study on Wistar rats regarding a possible carcinogenic effect of vinylidene chloride (VDC) were presented previously by one of the authors. Due to the unclear character of these results, a second inhalation study was initiated with Sprague-Dawley rats. Groups of 60 animals were exposed to 100 and 75 ppm VDC, along with one control group. A final report on the pathological results must await completion of the microscopic examination of the tissues and organs from all the animals. Nevertheless, it seems clear that there is no grossly observable interrelation between tumor production and VDC inhalation.

Full text

PDF
45

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. CARPENTER C. P., SMYTH H. F., Jr, POZZANI U. C. The assay of acute vapor toxicity, and the grading and interpretation of results on 96 chemical compounds. J Ind Hyg Toxicol. 1949 Nov;31(6):343–346. [PubMed] [Google Scholar]
  2. Gage J. C. The subacute inhalation toxicity of 109 industrial chemicals. Br J Ind Med. 1970 Jan;27(1):1–18. doi: 10.1136/oem.27.1.1. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Prendergast J. A., Jones R. A., Jenkins L. J., Jr, Siegel J. Effects on experimental animals of long-term inhalation of trichloroethylene, carbon tetrachloride, 1,1,1-trichloroethane, dichlorodifluoromethane, and 1,1-dichloroethylene. Toxicol Appl Pharmacol. 1967 Mar;10(2):270–289. doi: 10.1016/0041-008x(67)90110-x. [DOI] [PubMed] [Google Scholar]
  4. Viola P. L., Bigotti A., Caputo A. Oncogenic response of rat skin, lungs, and bones to vinyl chloride. Cancer Res. 1971 May;31(5):516–522. [PubMed] [Google Scholar]

Articles from Environmental Health Perspectives are provided here courtesy of National Institute of Environmental Health Sciences

RESOURCES