Skip to main content
Environmental Health Perspectives logoLink to Environmental Health Perspectives
. 1973 Dec;6:157–166. doi: 10.1289/ehp.7306157

Chromosome aberrations as a measure of mutagenesis: comparisons in vitro and in vivo and in somatic and germ cells.

J G Brewen, R J Preston
PMCID: PMC1475529  PMID: 4360724

Full text

PDF
157

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BREWEN J. G. STUDIES ON THE FREQUENCIES OF CHROMATID ABERRATIONS INDUCED BY X RAYS AT DIFFERENT TIMES OF THE CELL CYCLE OF VICIA FABA. Genetics. 1964 Jul;50:101–107. doi: 10.1093/genetics/50.1.101. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. BROCK N., HOHORST H. J. UBER DIE AKTIVIERUNG VON CYCLOPHOSPHAMID IN VIVO UND IN VITRO. Arzneimittelforschung. 1963 Dec;13:1021–1031. [PubMed] [Google Scholar]
  3. Brewen J. G., Gengozian N. Radiation-induced human chromosome aberrations. II. Human in vitro irradiation compared to in vitro and in vivo irradiation of marmoset leukocytes. Mutat Res. 1971 Dec;13(4):383–391. doi: 10.1016/0027-5107(71)90050-9. [DOI] [PubMed] [Google Scholar]
  4. Brewen J. G., Pearson F. G., Jones K. P., Luippold H. E. Cytogenetic effects of cyclohexylamine and N-OH-cyclohexylamine on human leucocytes and Chinese hamster bone marrow. Nat New Biol. 1971 Mar 3;230(1):15–16. doi: 10.1038/newbio230015a0. [DOI] [PubMed] [Google Scholar]
  5. Brewen J. G., Preston R. J., Jones K. P., Gosslee D. G. Genetic hazards of ionizing radiations: cytogenetic extrapolations from mouse to man. Mutat Res. 1973 Feb;17(2):245–254. doi: 10.1016/0027-5107(73)90173-5. [DOI] [PubMed] [Google Scholar]
  6. CATTANACH B. M. The sensitivity of the mouse testis to the mutagenic action of triethylenemelamine. Z Vererbungsl. 1959;90(1):1–6. doi: 10.1007/BF00888569. [DOI] [PubMed] [Google Scholar]
  7. Caspersson T., Haglund U., Lindell B., Zech L. Radiation-induced non-random chromosome breakage. Exp Cell Res. 1972 Dec;75(2):541–543. doi: 10.1016/0014-4827(72)90469-7. [DOI] [PubMed] [Google Scholar]
  8. Cattanach B. M., Pollard C. E., Isaacson J. H. Ethyl methanesulfonate-induced chromosome breakage in the mouse. Mutat Res. 1968 Sep-Oct;6(2):297–307. doi: 10.1016/0027-5107(68)90045-6. [DOI] [PubMed] [Google Scholar]
  9. Cattanach B. M., Williams C. E. A search for chromosome aberrations induced in mouse spermatogonia by chemical mutagens. Mutat Res. 1971 Dec;13(4):371–375. doi: 10.1016/0027-5107(71)90048-0. [DOI] [PubMed] [Google Scholar]
  10. Ford C. E., Searle A. G., Evans E. P., West B. J. Differential transmission of translocations induced in spermatogonia of mice by irradiation. Cytogenetics. 1969;8(6):447–470. doi: 10.1159/000130056. [DOI] [PubMed] [Google Scholar]
  11. Gerber G. B., Léonard A. Influence of selection, non-uniform cell population and repair on dose-effect curves of genetic effects. Mutat Res. 1971 Jun;12(2):175–182. doi: 10.1016/0027-5107(71)90139-4. [DOI] [PubMed] [Google Scholar]
  12. Heddle J. A. Randomness in the formation of radiation-indued chromosome aberrations. Genetics. 1965 Dec;52(6):1329–1334. doi: 10.1093/genetics/52.6.1329. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Legator M. S., Palmer K. A., Green S., Petersen K. W. Cytogenetic studies in rats of cyclohexylamine, a metabolite of cyclamate. Science. 1969 Sep 12;165(3898):1139–1140. doi: 10.1126/science.165.3898.1139. [DOI] [PubMed] [Google Scholar]
  14. Leonard A., Linden G. Observation of dividing spermatocytes for chromosome aberrations induced in mouse spermatogonia by chemical mutagens. Mutat Res. 1972 Nov;16(3):297–300. doi: 10.1016/0027-5107(72)90160-1. [DOI] [PubMed] [Google Scholar]
  15. Lyon M. F., Morris T. Gene and chromosome mutation after large fractionated or unfractionated radiation doses to mouse spermatogonia. Mutat Res. 1969 Jul-Aug;8(1):191–198. doi: 10.1016/0027-5107(69)90153-5. [DOI] [PubMed] [Google Scholar]
  16. MOORHEAD P. S., NOWELL P. C., MELLMAN W. J., BATTIPS D. M., HUNGERFORD D. A. Chromosome preparations of leukocytes cultured from human peripheral blood. Exp Cell Res. 1960 Sep;20:613–616. doi: 10.1016/0014-4827(60)90138-5. [DOI] [PubMed] [Google Scholar]
  17. McFee A. F., Banner M. W., Sherrill M. N. Chromosome aberrations in swine leukocytes after in vivo or in vitro exposure to 14 MeV neutrons. Radiat Res. 1970 Nov;44(2):512–522. [PubMed] [Google Scholar]
  18. Oftedal P. A theoretical study of mutant yield and cell killing after treatment of heterogeneous cell populations. Hereditas. 1968;60(1):177–210. doi: 10.1111/j.1601-5223.1968.tb02201.x. [DOI] [PubMed] [Google Scholar]
  19. Preston R. J., Brewen J. G., Jones K. P. Radiation-induced chromosome abberations in Chinese hamster leukocytes. A comparison of in vivo and in vitro exposures. Int J Radiat Biol Relat Stud Phys Chem Med. 1972 Apr;21(4):397–400. doi: 10.1080/09553007214550461. [DOI] [PubMed] [Google Scholar]
  20. RUSSELL L. B., RUSSELL W. L. Genetic analysis of induced deletions and of spontaneous nondisjunction involving chromosome 2 of the mouse. J Cell Comp Physiol. 1960 Nov;56(Suppl 1):169–188. doi: 10.1002/jcp.1030560415. [DOI] [PubMed] [Google Scholar]
  21. Russell L. B. Definition of functional units in a small chromosomal segment of the mouse and its use in interpreting the nature of radiation-induced mutations. Mutat Res. 1971 Jan;11(1):107–123. doi: 10.1016/0027-5107(71)90036-4. [DOI] [PubMed] [Google Scholar]
  22. Savage J. R., Papworth D. G. Distortion hypothesis: an alternative to a limited number of sites for radiation-induced chromosome exchange. J Theor Biol. 1969 Mar;22(3):493–514. doi: 10.1016/0022-5193(69)90017-4. [DOI] [PubMed] [Google Scholar]
  23. Schmid W., Arakaki D. T., Breslau N. A., Culbertson J. C. Chemical mutagenesis. The Chinese hamster bone marrow as an in vivo test system. I. Cytogenetic results on basic aspects of the methodology, obtained with alkylating agents. Humangenetik. 1971;11(2):103–118. doi: 10.1007/BF00393791. [DOI] [PubMed] [Google Scholar]
  24. Scott D., Evans H. J. X-ray-induced chromosomal aberrations in vicia faba: changes in response during the cell cycle. Mutat Res. 1967 Sep-Oct;4(5):579–599. doi: 10.1016/0027-5107(67)90044-9. [DOI] [PubMed] [Google Scholar]
  25. Searle A. G., Evans E. P., Beechey C. V. Evidence against a cytogenetically radioresistant spermatogonial population in male mice. Mutat Res. 1971 Jun;12(2):219–220. doi: 10.1016/0027-5107(71)90147-3. [DOI] [PubMed] [Google Scholar]

Articles from Environmental Health Perspectives are provided here courtesy of National Institute of Environmental Health Sciences

RESOURCES