Skip to main content
NCBI home page
Annals of Surgery logoLink to Annals of Surgery
. 1965 Oct;162(4):663–689. doi: 10.1097/00000658-196510000-00011

Enzyme alterable alkylating agents. 8. Clinical trials with intra-arterial infusion of an alkylating agent with a half-life of 0.2 second.

L E Goodman, A Ulfohn, S P Kramer, E H Cendana, A B Flores, D Bakal, S J Abrams, R L Hirschfeld, S Calle, C E Williamson, S Sass, B Witten, A M Seligman
PMCID: PMC1476944  PMID: 5319397

Full text

PDF
663

Images in this article

682Fig. 2 (Left)., Fig. 3 (Right).
on p.682
683Fig. 4 (Left)., Fig. 5 (Right).
on p.683
686Fig. 6.
on p.686

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BIERMAN H. R., MILLER E. R., BYRON R. L., DOD K. S., KELLY K. H., BLACK D. H. Intra-arterial catheterization of viscera in man. Am J Roentgenol Radium Ther. 1951 Oct;66(4):555–568. [PubMed] [Google Scholar]
  2. CLARKSON B., LAWRENCE W., Jr Perfusion and infusion techniques in cancer chemotherapy. Med Clin North Am. 1961 May;45:689–710. doi: 10.1016/s0025-7125(16)33881-0. [DOI] [PubMed] [Google Scholar]
  3. CONRAD M. E., Jr, CROSBY W. H. Massive nitrogen mustard therapy in Hodgkin's disease with protection of bone marrow by tourniquets. Blood. 1960 Aug;16:1089–1103. [PubMed] [Google Scholar]
  4. CREECH O., Jr, KREMENTZ E. T., RYAN R. F., WINBLAD J. N. Chemotherapy of cancer: regional perfusion utilizing an extracorporeal circuit. Ann Surg. 1958 Oct;148(4):616–632. doi: 10.1097/00000658-195810000-00009. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. GOODMAN L. E., BAKAL D., TSOU K. C., KRAMER S. P., ULFOHN A., GABY S. D., DORFMAN H. E., AYBAR O., CENDANA E., ASCOLI M. G. CLINICAL EXPERIENCE WITH N-HEXAMETHYLENE N'N'-DIETHYLENE THIOPHOSPHORAMIDE (KC-33), A NEW AGENT FOR BREAST AND OVARIAN CARCINOMA. Cancer. 1965 Mar;18:307–312. doi: 10.1002/1097-0142(196503)18:3<307::aid-cncr2820180307>3.0.co;2-n. [DOI] [PubMed] [Google Scholar]
  6. GOODMAN L. E., SCHILLING A., KRAMER S. P., ULFOHN A., MILLER S., KRAVITZ S., GABY S. D., BAKAL D., WITTEN B., SELIGMAN A. M. Effective use of a new alkylating agent in doses lethal to bone marrow with protection by tourniquets of marrow in the extremis. Surg Forum. 1961;12:130–132. [PubMed] [Google Scholar]
  7. JACOB S. W., BISCHEL M., HERSCHLER R. J. DIMETHYL SULFOXIDE (DMSO): A NEW CONCEPT IN PHARMACOTHERAPY. Curr Ther Res Clin Exp. 1964 Feb;6:134–135. [PubMed] [Google Scholar]
  8. KLOPP C. T., ALFORD T. C., BATEMAN J., BERRY G. N., WINSHIP T. Fractionated intra-arterial cancer; chemotherapy with methyl bis amine hydrochloride; a preliminary report. Ann Surg. 1950 Oct;132(4):811–832. doi: 10.1097/00000658-195010000-00018. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. LAWRENCE W., Jr, KUEHN P., MASLE E. T., MILLER D. G. An abdominal tourniquet for regional chemotherapy. J Surg Res. 1961 Jul;1:142–151. doi: 10.1016/s0022-4804(61)80011-5. [DOI] [PubMed] [Google Scholar]
  10. SASS S., WILLIAMSON C. E., KRAMER S. P., GOODMAN L. E., ULFOHN A., SELIGMAN A. M., WITTEN B. ENZYME-ALTERABLE ALKYLATING AGENTS. VII. THE DESIGN OF SHORT-LIVED MUSTARDS. J Med Chem. 1965 Jan;8:14–17. doi: 10.1021/jm00325a003. [DOI] [PubMed] [Google Scholar]
  11. SCHILLING A. Enzyme-alterable alkylating agents. IV. Treatment of cancer in children with repetitive massive doses of S-46, protecting the extremity marrow by tourniquets. Cancer. 1963 Jun;16:727–736. doi: 10.1002/1097-0142(196306)16:6<727::aid-cncr2820160607>3.0.co;2-2. [DOI] [PubMed] [Google Scholar]
  12. SELIGMAN A. M. Enzyme alterable alkylating agents: a new approach to regional chemotherapy by intra-arterial infusion of new short-lived alkylating agents. Ann Surg. 1962 Sep;156:429–441. doi: 10.1097/00000658-196209000-00010. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. SULLIVAN R. D. Continuous arterial infusion of methotrexate with intermittent, intramuscular citrovorum factor therapy in head and neck cancer. Trans Pac Coast Otoophthalmol Soc Annu Meet. 1961;42:29–42. [PubMed] [Google Scholar]
  14. SULLIVAN R. D., JONES R., Jr, SCHNABEL T. G., Jr, SHOREY J. M. The treatment of human cancer with intra-arterial nitrogen mustard, methylbis (2-chloroethyl) amine hydrochloride, utilizing a simplified catheter technique. Cancer. 1953 Jan;6(1):121–134. doi: 10.1002/1097-0142(195301)6:1<121::aid-cncr2820060112>3.0.co;2-6. [DOI] [PubMed] [Google Scholar]
  15. SULLIVAN R. D., MILLER E., SIKES M. P. Antimetabolite-metabolite combination cancer chemotherapy. Effects of intraarterial methotrexate-intramuscular Citrovorum factor therapy in human cancer. Cancer. 1959 Nov-Dec;12:1248–1262. doi: 10.1002/1097-0142(195911/12)12:6<1248::aid-cncr2820120619>3.0.co;2-2. [DOI] [PubMed] [Google Scholar]
  16. Seligman A. M., Nachlas M. M., Manheimer L. H., Friedman O. M., Wolf G. Development of New Methods for the Histochemical Demonstration of Hydrolytic Intracellular Enzymes in a Program of Cancer Research. Ann Surg. 1949 Sep;130(3):333–341. [PMC free article] [PubMed] [Google Scholar]
  17. WATKINS E., Jr, HERING A. C., LUNA R., ADAMS H. D. The use of intravascular balloon catheters for isolation of the pelvic vascular bed during pump-oxygenator perfusion of cancer chemotherapeutic agents. Surg Gynecol Obstet. 1960 Oct;111:464–468. [PubMed] [Google Scholar]
  18. WILLIAMSON C. E., MILLER J. I., SASS S., CASANOVA J., KRAMER S. P., SELIGMAN A. M., WITTEN B. ENZYME ALTERABLE ALKYLATING AGENTS. V. DESIGN OF SULFUR MUSTARDS WITH VARYING DEGREES OF HYDROLYTIC STABILITY IN A SEARCH FOR SHORT BIOLOGICAL HALF-LIFE AGENTS. J Natl Cancer Inst. 1963 Aug;31:273–296. [PubMed] [Google Scholar]
  19. WITTEN B., WILLIAMSON C. E., MILLER J. I., SASS S., KRAMER S. P., GOODMAN L. E., ULFOHN A., SELIGMAN A. M. New short half-life alkylating agents for intra-arterial regional chemotherapy. Cancer Chemother Rep. 1962 Feb;16:515–516. [PubMed] [Google Scholar]

Articles from Annals of Surgery are provided here courtesy of Lippincott, Williams, and Wilkins

RESOURCES