Case Report
A 53-year-old man with a prostate-specific antigen (PSA) level of 4.2 ng/dL has a benign 40 g prostate on digital rectal examination. The patient undergoes a 12-core biopsy of the prostate, which shows a single focus of prostatic intraepithelial neoplasia (Figure 1).
Figure 1.
High-grade prostatic intraepithelial neoplasia: micropapillary pattern (hematoxylin and eosin, × 400).
Management Options
The next appropriate step in the management of this patient would be:
Immediate repeat 12-core biopsy
Immediate repeat saturation biopsy
Immediate repeat biopsy of transition zone
Repeat biopsy in 1 year
Repeat biopsy in 3 years independent of PSA change
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