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. 1992 Mar;33(3):175, 178-183.

The effects of treatment with cloprostenol or dinoprost within one hour of induced parturition on the incidence of retained placenta in cattle

Antonio Garcia, Albert D Barth, Reuben J Mapletoft
PMCID: PMC1481189  PMID: 17423964

Abstract

Two experiments were designed to determine whether prostaglandin treatment within one hour postpartum would reduce the incidence of retained placentas after induction of parturition in beef cattle. In the first experiment, 70 cows were induced on day 276-278 of gestation with the combination of 500 μg cloprostenol and 25 mg dexamethasone (CP + Dex). Within one hour after parturition, cows received either 500 μg CP or 25 mg of dinoprost (DI). The incidence of retained placenta (RP) was 64.3% in induced groups and 0% in noninduced control cows and postpartum treatment with either CP or DI had no effect on placental retention.

A second experiment, utilizing 132 cows and heifers, was conducted to determine whether induction with Dex alone, rather than with CP + Dex, would influence the rate of placental retention after postpartum treatment with either CP or DI. The incidence of retained placenta ranged from 28.5 to 58.3% in induced females but was 0% in noninduced control females. As in the first experiment, postpartum prostaglandin treatment had no effect on placental retention.

The results of these experiments do not support the use of prostaglandins within one hour of induced parturition to reduce the incidence of retained placentas.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Adams W. M. The elective induction of labor and parturition in cattle. J Am Vet Med Assoc. 1969 Feb 1;154(3):261–268. [PubMed] [Google Scholar]
  2. Adams W. M., Wagner W. C. The role of corticoids in parturition. Biol Reprod. 1970 Oct;3(2):223–228. doi: 10.1093/biolreprod/3.2.223. [DOI] [PubMed] [Google Scholar]
  3. Agthe O., Kolm H. P. Oestrogen and progesterone levels in the blood plasma of cows with normal parturition or with a retained placenta. J Reprod Fertil. 1975 Apr;43(1):163–166. doi: 10.1530/jrf.0.0430163. [DOI] [PubMed] [Google Scholar]
  4. Barth A. D., Adams W. M., Manns J. C., Rawlings N. C. Induction of parturition in beef cattle using estrogens in conjunction with dexamethasone. Can Vet J. 1978 Jul;19(7):175–180. [PMC free article] [PubMed] [Google Scholar]
  5. Beardsley G. L., Muller L. D., Garverick H. A., Ludens F. C., Tucker W. L. Initiation of parturition in dairy cows with dexamethasone. II. Response to dexamethasone in combination with estradiol benzoate. J Dairy Sci. 1976 Feb;59(2):241–247. doi: 10.3168/jds.S0022-0302(76)84190-2. [DOI] [PubMed] [Google Scholar]
  6. Beardsley G. L., Muller L. D., Owens M. J., Ludens F. C., Tucker W. L. Initiation of parturition in dairy cows with dexamethasone. I. Cow response and performance. J Dairy Sci. 1974 Sep;57(9):1061–1066. doi: 10.3168/jds.S0022-0302(74)85009-5. [DOI] [PubMed] [Google Scholar]
  7. Bolinder A., Seguin B., Kindahl H., Bouley D., Otterby D. Retained fetal membranes in cows: Manual removal versus nonremoval and its effect on reproductive performance. Theriogenology. 1988 Jul;30(1):45–56. doi: 10.1016/0093-691x(88)90262-2. [DOI] [PubMed] [Google Scholar]
  8. Chew B. P., Keller H. F., Erb R. E., Malven P. V. Periparturient concentrations of prolactin, progesterone and the estrogens in blood plasma of cows retaining and not retaining fetal membranes. J Anim Sci. 1977 Jun;44(6):1055–1060. doi: 10.2527/jas1977.4461055x. [DOI] [PubMed] [Google Scholar]
  9. Claydon R. K. Induction of parturition in cattle during the later stages of pregnancy: a comparison of three treatments. Vet Rec. 1984 Feb 4;114(5):113–114. doi: 10.1136/vr.114.5.113. [DOI] [PubMed] [Google Scholar]
  10. Davis D. L., Kesler D. J., Jenkins A. L., Garverick H. A., Massey J. W., Bierschwal C. J., Day B. N. Induction of parturition in cattle with long and short acting corticoids and estradiol benzoate. J Anim Sci. 1979 Aug;49(2):560–566. doi: 10.2527/jas1979.492560x. [DOI] [PubMed] [Google Scholar]
  11. Day A. M. Cloprostenol for termination of pregnancy in cattle. A) The induction of parturition. N Z Vet J. 1977 Jun;25(6):136–139. doi: 10.1080/00480169.1977.34385. [DOI] [PubMed] [Google Scholar]
  12. Echternkamp S. E., Hays W. G., Kvasnicka W. G. Synchronization of parturition in beef cattle with prostaglandin and dexamethasone. Theriogenology. 1987 Sep;28(3):337–347. doi: 10.1016/0093-691x(87)90021-5. [DOI] [PubMed] [Google Scholar]
  13. Eiler H., Hopkins F. M., Armstrong-Backus C. S., Lyke W. A. Uterotonic effect of prostaglandin F2 alpha and oxytocin on the postpartum cow. Am J Vet Res. 1984 May;45(5):1011–1014. [PubMed] [Google Scholar]
  14. Evans L. E., Wagner W. C. Bovine plasma oestrogens, progesterone and glucocorticoids during dexamethasone induced parturition. Acta Endocrinol (Copenh) 1976 Feb;81(2):385–397. doi: 10.1530/acta.0.0810385. [DOI] [PubMed] [Google Scholar]
  15. Fairclough R. J., Hunter J. T., Welch R. A. Peripheral plasma progesterone and utero-ovarian prostaglandin F concentrations in the cow around parturition. Prostaglandins. 1975 Jun;9(6):901–914. doi: 10.1016/0090-6980(75)90078-7. [DOI] [PubMed] [Google Scholar]
  16. Garverick H. A., Day B. N., Mather E. C., Gomez L., Thompson G. B. Use of estrogen with dexamethasone for inducing parturition in beef cattle. J Anim Sci. 1974 Mar;38(3):584–590. doi: 10.2527/jas1974.383584x. [DOI] [PubMed] [Google Scholar]
  17. Gross T. S., Williams W. F., Moreland T. W. Prevention of the retained fetal membrane syndrome (retained placenta) during induced calving in dairy cattle. Theriogenology. 1986 Sep;26(3):365–370. doi: 10.1016/0093-691x(86)90156-1. [DOI] [PubMed] [Google Scholar]
  18. Henricks D. M., Rawlings N. C., Ellicott A. R., Dickey J. F., Hill J. R. Use of prostaglandin F2alpha to induce parturition in beef heifers. J Anim Sci. 1977 Mar;44(3):438–441. doi: 10.2527/jas1977.443438x. [DOI] [PubMed] [Google Scholar]
  19. Henricks D. M., Rawlings N. C., Ellicott A. R. Plasma hormone levels in beef heifers during prostaglandin-induced parturition. Theriogenology. 1977 Jan;7(1):17–27. doi: 10.1016/0093-691x(77)90264-3. [DOI] [PubMed] [Google Scholar]
  20. Horta A. E., Chassagne M., Brochart M. Prostaglandin F2 alpha and prostacyclin imbalance in cows with placental retention: new findings. Ann Rech Vet. 1986;17(4):395–400. [PubMed] [Google Scholar]
  21. Hunter J. T., Fairclough R. J., Peterson A. J., Welch R. A. Foetal and maternal hormonal changes preceding normal bovine parturition. Acta Endocrinol (Copenh) 1977 Mar;84(3):653–662. doi: 10.1530/acta.0.0840653. [DOI] [PubMed] [Google Scholar]
  22. Johnson C. T., Jackson P. S. Induction of parturition in cattle with cloprostenol. Br Vet J. 1982 May-Jun;138(3):212–224. doi: 10.1016/s0007-1935(17)31085-0. [DOI] [PubMed] [Google Scholar]
  23. Johnson W. H., Manns J. G., Adams W. M., Mapletoft R. J. Termination of pregnancy with cloprostenol and dexamethasone in intact or ovariectomized cows. Can Vet J. 1981 Sep;22(9):288–290. [PMC free article] [PubMed] [Google Scholar]
  24. Kesler D. J., Peterson R. C., Erb R. E., Callahan C. J. Concentrations of hormones in blood and milk during and after induction of parturition in beef cattle with dexamethasone and estradiol-17beta. J Anim Sci. 1976 Apr;42(4):918–926. doi: 10.2527/jas1976.424918x. [DOI] [PubMed] [Google Scholar]
  25. LaVoie V. A., Moody E. L. Estrogen pre-treatment of corticoid induced parturition in cattle. J Anim Sci. 1973 Sep;37(3):770–775. doi: 10.2527/jas1973.373770x. [DOI] [PubMed] [Google Scholar]
  26. Leidl W., Hegner D., Rockel Investigations on the PGF2a concentration in maternal and foetal cotyledons of cows with and without retained foetal membranes. Zentralbl Veterinarmed A. 1980;27(9-10):691–696. doi: 10.1111/j.1439-0442.1980.tb02019.x. [DOI] [PubMed] [Google Scholar]
  27. Lewing F. J., Proulx J., Mapletoft R. J. Induction of Parturition in the Cow using Cloprostenol and Dexamethasone in Combination. Can Vet J. 1985 Oct;26(10):317–322. [PMC free article] [PubMed] [Google Scholar]
  28. Lindell J. O., Kindahl H., Edqvist L. E. Prostaglandin release at dexamethasone induced parturitions in cows. Acta Vet Scand. 1977;18(2):257–265. doi: 10.1186/BF03548454. [DOI] [PMC free article] [PubMed] [Google Scholar]
  29. Morrison D. G., Humes P. E., Godke R. A. The use of dimenhydrinate in conjunction with dexamethasone for induction of parturition in beef cattle. Theriogenology. 1983 Feb;19(2):221–233. doi: 10.1016/0093-691x(83)90008-0. [DOI] [PubMed] [Google Scholar]
  30. Muller L. D., Beardsley G. L., Ellis R. P., Reed D. E., Owens M. J. Calf response to the initiation of parturition in dairy cows with dexamethasone or dexamethasone with estradiol benzoate. J Anim Sci. 1975 Dec;41(6):1711–1716. doi: 10.2527/jas1975.4161711x. [DOI] [PubMed] [Google Scholar]
  31. Musah A. I., Schwabe C., Willham R. L., Anderson L. L. Induction of parturition, progesterone secretion, and delivery of placenta in beef heifers given relaxin with cloprostenol or dexamethasone. Biol Reprod. 1987 Nov;37(4):797–803. doi: 10.1095/biolreprod37.4.797. [DOI] [PubMed] [Google Scholar]
  32. Ottobre J. S., Inskeep E. K. Synchronization of parturition in beef cattle using delay as well as induction. Theriogenology. 1983 Sep;20(3):267–277. doi: 10.1016/0093-691x(83)90060-2. [DOI] [PubMed] [Google Scholar]
  33. Peter A. T., Bosu W. T. Peripartal endocrine changes associated with retained placenta in dairy cows. Theriogenology. 1987 Sep;28(3):383–394. doi: 10.1016/0093-691x(87)90026-4. [DOI] [PubMed] [Google Scholar]
  34. Pimentel S. M., Pimentel C. A., Weston P. G., Hixon J. E., Wagner W. C. Progesterone secretion by the bovine fetoplacental unit and responsiveness of corpora lutea to steroidogenic stimuli at two stages of gestation. Am J Vet Res. 1986 Sep;47(9):1967–1971. [PubMed] [Google Scholar]
  35. Rodbard D. Statistical quality control and routine data processing for radioimmunoassays and immunoradiometric assays. Clin Chem. 1974 Oct;20(10):1255–1270. [PubMed] [Google Scholar]
  36. Smith V. G., Edgerton L. A., Hafs H. D., Convey E. M. Bovine serum estrogens, progestins and glucocorticoids during late pregnancy parturition and early lactation. J Anim Sci. 1973 Feb;36(2):391–396. doi: 10.2527/jas1973.362391x. [DOI] [PubMed] [Google Scholar]
  37. Terblanche H. M., Labuschagne J. M. Induced parturition in cattle. II. Plasma oestrogen and progesterone levels. J S Afr Vet Assoc. 1980 Jun;51(2):101–103. [PubMed] [Google Scholar]
  38. Thorburn G. D., Challis J. R., Currie W. B. Control of parturition in domestic animals. Biol Reprod. 1977 Feb;16(1):18–27. doi: 10.1095/biolreprod16.1.18. [DOI] [PubMed] [Google Scholar]
  39. Wagner W. C., Willham R. L., Evans L. E. Controlled parturition in cattle. J Anim Sci. 1974 Mar;38(3):485–489. doi: 10.2527/jas1974.383485x. [DOI] [PubMed] [Google Scholar]
  40. Welch R. A., Newling P., Anderson D. Induction of parturition in cattle with corticosteroids: an analysis of field trials. N Z Vet J. 1973 Jun;21(6):103–108. doi: 10.1080/00480169.1973.34087. [DOI] [PubMed] [Google Scholar]
  41. Zerobin K., Jöchle W., Steingruber C. Termination of pregnancy with prostaglandins E2 (PGE2) and F2alpha (PGF2alpha) in cattle. Prostaglandins. 1973 Dec;4(6):891–901. doi: 10.1016/0090-6980(73)90124-x. [DOI] [PubMed] [Google Scholar]

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