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. 1992 Apr;33(4):251–256.

Hemorrhagic gastroenteritis caused by Escherichia coli in piglets: Clinical, pathological and microbiological findings

Claude Faubert, Richard Drolet
PMCID: PMC1481210  PMID: 17423984

Abstract

A retrospective study (1980-1989) was conducted to describe the clinical, pathological, and bacteriological findings in 55 cases of hemorrhagic gastroenteritis (HGE) caused by Escherichia coli in piglets. The condition occurred in weaned and suckling piglets and was associated with several serogroups of E. coli. Most of the isolates of E. coli possessed the adhesin F4 (K88) and were hemolytic. Only a few of the isolates of E. coli tested produced verotoxins. Clinical signs and pathological findings noted in these cases were compatible with shock.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bohach G. A., Snyder I. S. Chemical and immunological analysis of the complex structure of Escherichia coli alpha-hemolysin. J Bacteriol. 1985 Dec;164(3):1071–1080. doi: 10.1128/jb.164.3.1071-1080.1985. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Brown J. E., Rothman S. W., Doctor B. P. Inhibition of protein synthesis in intact HeLa cells by Shigella dysenteriae 1 toxin. Infect Immun. 1980 Jul;29(1):98–107. doi: 10.1128/iai.29.1.98-107.1980. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Cavalieri S. J., Bohach G. A., Snyder I. S. Escherichia coli alpha-hemolysin: characteristics and probable role in pathogenicity. Microbiol Rev. 1984 Dec;48(4):326–343. doi: 10.1128/mr.48.4.326-343.1984. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Clugston R. E., Nielsen N. O. Experimental edema disease of swine (E. coli enterotoxemia). I. Dectection and preparation of an active principle. Can J Comp Med. 1974 Jan;38(1):22–28. [PMC free article] [PubMed] [Google Scholar]
  5. Dam A., Knox B. Haemolytic Escherichia coli associated with enteritis and enterotoxaemia in pigs in Denmark, with particular reference to the rapid spread of serogroup 0149:K91. Nord Vet Med. 1974 Mar;26(3):219–225. [PubMed] [Google Scholar]
  6. Fairbrother J. M., Larivière S., Johnson W. M. Prevalence of fimbrial antigens and enterotoxins in nonclassical serogroups of Escherichia coli isolated from newborn pigs with diarrhea. Am J Vet Res. 1988 Aug;49(8):1325–1328. [PubMed] [Google Scholar]
  7. Gaastra W., de Graaf F. K. Host-specific fimbrial adhesins of noninvasive enterotoxigenic Escherichia coli strains. Microbiol Rev. 1982 Jun;46(2):129–161. doi: 10.1128/mr.46.2.129-161.1982. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Gannon V. P., Gyles C. L., Friendship R. W. Characteristics of verotoxigenic Escherichia coli from pigs. Can J Vet Res. 1988 Jul;52(3):331–337. [PMC free article] [PubMed] [Google Scholar]
  9. Gannon V. P., Gyles C. L., Wilcock B. P. Effects of Escherichia coli Shiga-like toxins (verotoxins) in pigs. Can J Vet Res. 1989 Jul;53(3):306–312. [PMC free article] [PubMed] [Google Scholar]
  10. Kashiwazaki M., Ogawa T., Isayama Y., Akaike Y., Tamura K., Sakazaki R. Detection of Vero cytotoxic strains of Escherichia coli isolated from diseased animals. Natl Inst Anim Health Q (Tokyo) 1980 Fall;20(3):116–117. [PubMed] [Google Scholar]
  11. Konowalchuk J., Speirs J. I., Stavric S. Vero response to a cytotoxin of Escherichia coli. Infect Immun. 1977 Dec;18(3):775–779. doi: 10.1128/iai.18.3.775-779.1977. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Kurtz H. J., Short E. C., Jr Pathogenesis of edema disease in swine: pathologic effects of hemolysin, autolysate, and endotoxin of Escherichia coli (O141). Am J Vet Res. 1976 Jan;37(1):15–24. [PubMed] [Google Scholar]
  13. Larivière S., Lallier R. Escherichia coli strains isolated from diarrheic piglets in the Province of Quebec. Can J Comp Med. 1976 Apr;40(2):190–197. [PMC free article] [PubMed] [Google Scholar]
  14. Lillehei R. C., Dietzman R. H., Movsas S. The visceral circulation in shock. Gastroenterology. 1967 Feb;52(2):468–471. [PubMed] [Google Scholar]
  15. Lundgren O. Studies on blood flow distribution and countercurrent exchange in the small intestine. Acta Physiol Scand Suppl. 1967;303:1–42. doi: 10.1111/j.1748-1716.1967.tb03885.x. [DOI] [PubMed] [Google Scholar]
  16. Moon H. W. Pathogenesis of enteric diseases caused by Escherichia coli. Adv Vet Sci Comp Med. 1974;18(0):179–211. [PubMed] [Google Scholar]
  17. Morin M., Morehouse L. G., Solorzano R. F., Olson L. D. Transmissible gastroenteritis in feeder swine: clinical, immunofluorescence and histopathological obervations. Can J Comp Med. 1973 Jul;37(3):239–248. [PMC free article] [PubMed] [Google Scholar]
  18. Nolan J. P., Hare D. K., McDevitt J. J., Ali M. V. In vitro studies of intestinal endotoxin absorption. I. Kinetics of absorption in the isolated everted gut sac. Gastroenterology. 1977 Mar;72(3):434–439. [PubMed] [Google Scholar]
  19. O'Brien A. D., LaVeck G. D. Purification and characterization of a Shigella dysenteriae 1-like toxin produced by Escherichia coli. Infect Immun. 1983 May;40(2):675–683. doi: 10.1128/iai.40.2.675-683.1983. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. O'Brien A. D., LaVeck G. D., Thompson M. R., Formal S. B. Production of Shigella dysenteriae type 1-like cytotoxin by Escherichia coli. J Infect Dis. 1982 Dec;146(6):763–769. doi: 10.1093/infdis/146.6.763. [DOI] [PubMed] [Google Scholar]
  21. Pai C. H., Kelly J. K., Meyers G. L. Experimental infection of infant rabbits with verotoxin-producing Escherichia coli. Infect Immun. 1986 Jan;51(1):16–23. doi: 10.1128/iai.51.1.16-23.1986. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. RAVIN H. A., ROWLEY D., JENKINS C., FINE J. On the absorption of bacterial endotoxin from the gastro-intestinal tract of the normal and shocked animal. J Exp Med. 1960 Nov 1;112:783–792. doi: 10.1084/jem.112.5.783. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. RICHARDS W. P., FRASER C. M. Coliform enteritis of weaned pigs. A description of the disease and its association with hemolytic Escherichia coli. Cornell Vet. 1961 Apr;51:245–257. [PubMed] [Google Scholar]
  24. SMITH H. W. The haemolysins of Escherichia coli. J Pathol Bacteriol. 1963 Jan;85:197–211. doi: 10.1002/path.1700850119. [DOI] [PubMed] [Google Scholar]
  25. Shreeve B. J., Thomlinson J. R. Absorption of Escherichia coli endotoxin by the neonatal pig. J Med Microbiol. 1972 Feb;5(1):55–59. doi: 10.1099/00222615-5-1-55. [DOI] [PubMed] [Google Scholar]
  26. Smith H. W., Green P., Parsell Z. Vero cell toxins in Escherichia coli and related bacteria: transfer by phage and conjugation and toxic action in laboratory animals, chickens and pigs. J Gen Microbiol. 1983 Oct;129(10):3121–3137. doi: 10.1099/00221287-129-10-3121. [DOI] [PubMed] [Google Scholar]
  27. Smith H. W., Linggood M. A. Observations on the pathogenic properties of the K88, Hly and Ent plasmids of Escherichia coli with particular reference to porcine diarrhoea. J Med Microbiol. 1971 Nov;4(4):467–485. doi: 10.1099/00222615-4-4-467. [DOI] [PubMed] [Google Scholar]
  28. Svendsen J. Enteric Escherichia coli diseases in weaned pigs. Nord Vet Med. 1974 Mar;26(3):226–238. [PubMed] [Google Scholar]
  29. Swan H. L., Press A. N., Briggs S. L. Child sexual abuse prevention: does it work? Child Welfare. 1985 Jul-Aug;64(4):395–405. [PubMed] [Google Scholar]
  30. THOMLINSON J. R., BUXTON A. Anaphylaxis in pigs and its relationship to the pathogenesis of oedema disease and gastro-enteritis associated with Escherichia coli. Immunology. 1963 Mar;6:126–139. [PMC free article] [PubMed] [Google Scholar]
  31. WIZNITZER T., SCHWEINBURG F. B., ATKINS N., FINE J. On the relation of the size of the intraintestinal pool of endotoxin to the development of irreversibility in hemorrhagic shock. J Exp Med. 1960 Dec 1;112:1167–1171. doi: 10.1084/jem.112.6.1167. [DOI] [PMC free article] [PubMed] [Google Scholar]
  32. Welch R. A., Dellinger E. P., Minshew B., Falkow S. Haemolysin contributes to virulence of extra-intestinal E. coli infections. Nature. 1981 Dec 17;294(5842):665–667. doi: 10.1038/294665a0. [DOI] [PubMed] [Google Scholar]

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