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Nucleic Acids Research logoLink to Nucleic Acids Research
. 1999 Jan 1;27(1):254–256. doi: 10.1093/nar/27.1.254

SCOP: a Structural Classification of Proteins database.

T J Hubbard 1, B Ailey 1, S E Brenner 1, A G Murzin 1, C Chothia 1
PMCID: PMC148149  PMID: 9847194

Abstract

The Structural Classification of Proteins (SCOP) database provides a detailed and comprehensive description of the relationships of all known proteins structures. The classification is on hierarchical levels: the first two levels, family and superfamily, describe near and far evolutionary relationships; the third, fold, describes geometrical relationships. The distinction between evolutionary relationships and those that arise from the physics and chemistry of proteins is a feature that is unique to this database, so far. The database can be used as a source of data to calibrate sequence search algorithms and for the generation of population statistics on protein structures. The database and its associated files are freely accessible from a number of WWW sites mirrored from URL http://scop. mrc-lmb.cam.ac.uk/scop/

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