Abstract
In normal platelets a proportionality was found between the amount of adenosine triphosphate (ATP) and amount of 5-hydroxytryptamine (5-HT) in platelets both before and after incubating them in plasma to which 5-HT had been added. In patients receiving reserpine and in others with myeloid leukaemia, the amount of 5-HT in the platelets and the uptake of 5-HT by them were depressed, while the amount of ATP was normal. The possibility that ATP is involved in the accumulation of 5-HT by platelets is discussed.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- BLASCHKO H., BORN G. V., D'IORIO A., EADE N. R. Observations on the distribution of catechol amines and adenosinetriphosphate in the bovine adrenal medulla. J Physiol. 1956 Sep 27;133(3):548–557. doi: 10.1113/jphysiol.1956.sp005607. [DOI] [PMC free article] [PubMed] [Google Scholar]
- HARDISTY R. M., INGRAM G. I., STACEY R. S. Reserpine and human platelet 5-hydroxytryptamine. Experientia. 1956 Nov 15;12(11):424–425. doi: 10.1007/BF02157365. [DOI] [PubMed] [Google Scholar]
- HARDISTY R. M., STACEY R. S. 5-Hydroxytryptamine in normal human platelets. J Physiol. 1955 Dec 29;130(3):711–720. doi: 10.1113/jphysiol.1955.sp005437. [DOI] [PMC free article] [PubMed] [Google Scholar]
- STREHLER B. L., TOTTER J. R. Determination of ATP and related compounds: firefly luminescence and other methods. Methods Biochem Anal. 1954;1:341–356. doi: 10.1002/9780470110171.ch13. [DOI] [PubMed] [Google Scholar]