Abstract
The action of atropine, in preventing pancreatic secretion in response to a parasympathomimetic drug, is analysed. Atropine does not appear to affect the uptake of glycine by the pancreatic cell, or the incorporation of radioactive amino acids into the total pancreatic tissue proteins, or into the proteins of the zymogen granules. The rate of amylase resynthesis in stimulated glands is not affected by atropine. It is suggested that atropine blocks pancreatic secretion in rats by blocking the extrusion of zymogen granules.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- HOKIN L. E. Isolation of the zymogen granules of dog pancreas and a study of their properties. Biochim Biophys Acta. 1955 Nov;18(3):379–388. doi: 10.1016/0006-3002(55)90101-3. [DOI] [PubMed] [Google Scholar]
- ROTHSCHILD H. A., HIRSCH G. C., JUNQUEIRA L. C. Radioactive amino acid incorporation into the rat pancreatic juice proteins. Experientia. 1957 Apr 15;13(4):158–159. doi: 10.1007/BF02158147. [DOI] [PubMed] [Google Scholar]