Abstract
Comparison was made on conscious trained dogs of the effect of highly purified arginine vasopressin and lysine vasopressin on the rate of urine flow, the excretion rate of Na and K and the renal clearances of creatinine and diodone, and of the actions of the vasopressins when administered together with oxytocin. The vasopressins were used in doses causing a maximal antidiuresis.
The results showed, first, that the antidiuretic potency of arginine vasopressin was greater than that of lysine vasopressin and that its action lasted longer; second, that during water diuresis arginine vasopressin increased only Na excretion while lysine vasopressin increased both Na and K excretion; third, that arginine vasopressin had a potency about 5 to 6 times that of lysine vasopressin in antagonizing the augmentor effect of oxytocin on glomerular filtration rate and renal plasma flow.
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Selected References
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- ABRAHAMS V. C., PICKFORD M. Simultaneous observations on the rate of urine flow and spontaneous uterine movements in the dog, and their relationship to posterior lobe activity. J Physiol. 1954 Nov 29;126(2):329–346. doi: 10.1113/jphysiol.1954.sp005213. [DOI] [PMC free article] [PubMed] [Google Scholar]
- ANSLOW W. P., Jr, WESSON L. G., Jr Some effects of pressor-antidiuretic and oxytocic fractions of posterior pituitary extract on sodium, chloride, potassium and ammonium excretion in the dog. Am J Physiol. 1955 Sep;182(3):561–566. doi: 10.1152/ajplegacy.1955.182.3.561. [DOI] [PubMed] [Google Scholar]
- Dicker S. E., Heller H. The renal action of posterior pituitary extract and its fractions as analysed by clearance experiments on rats. J Physiol. 1946 Apr 15;104(4):353–360. [PMC free article] [PubMed] [Google Scholar]
- MAXWELL M. H., BREED E. S. The effect of the intravenous administration of pitressin on renal function in man. J Pharmacol Exp Ther. 1951 Oct;103(2):190–195. [PubMed] [Google Scholar]
- Rehberg P. B. Studies on Kidney Function: The Rate of Filtration and Reabsorption in the Human Kidney. Biochem J. 1926;20(3):447–460. doi: 10.1042/bj0200447. [DOI] [PMC free article] [PubMed] [Google Scholar]
- TURNER R. A., PIERCE J. G., DU VIGNEAUD V. The desulfurization of oxytocin. J Biol Chem. 1951 Nov;193(1):359–361. [PubMed] [Google Scholar]
- VAN DYKE H. B., ENGEL S. L., ADAMSONS K., Jr Comparison of pharmacological effects of lysine and arginine vasopressins. Proc Soc Exp Biol Med. 1956 Mar;91(3):484–486. doi: 10.3181/00379727-91-22300. [DOI] [PubMed] [Google Scholar]