Abstract
The introduction of substance P into the lumen of the isolated guinea-pig ileum caused an increase in the number and amplitude of the peristaltic waves. In preparations in which the peristaltic reflex was abolished, by fatigue, by external or internal application of 5-hydroxytryptamine, or by lowering the temperature of the bath, the introduction of substance P into the lumen of the intestine restored peristalsis. This effect of substance P was absent in preparations in which the mucous membrane was removed. Hexamethonium abolished the effect of substance P on peristalsis. It is concluded that substance P acts on the afferent nervous elements of the peristaltic reflex arc, possibly on the sensory receptors.
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Selected References
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- BELESLIN D., VARAGIC V. The effect of cooling and of 5-hydroxytryptamine on the peristaltic reflex of the isolated guinea-pig ileum. Br J Pharmacol Chemother. 1958 Sep;13(3):266–270. doi: 10.1111/j.1476-5381.1958.tb00901.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- BLAIR M. R., CLARK B. B. An evaluation of the action of substance P on the jejunum of the rabbit. J Pharmacol Exp Ther. 1956 Aug;117(4):467–477. [PubMed] [Google Scholar]
- BULBRING E., LIN R. C., SCHOFIELD G. An investigation of the peristaltic reflex in relation to anatomical observations. Q J Exp Physiol Cogn Med Sci. 1958 Jan;43(1):26–37. doi: 10.1113/expphysiol.1958.sp001305. [DOI] [PubMed] [Google Scholar]
- DOUGLAS W. W., FELDBERG W., PATON W. D. M., SCHACHTER M. Distribution of histamine and substance P in the wall of the dog's digestive tract. J Physiol. 1951 Oct 29;115(2):163–176. doi: 10.1113/jphysiol.1951.sp004661. [DOI] [PMC free article] [PubMed] [Google Scholar]
- DUNER H., VON EULER U. S., PERNOW B. Catechol amines and substance P in the mammalian eye. Acta Physiol Scand. 1954 Jul 18;31(2-3):113–114. doi: 10.1111/j.1748-1716.1954.tb01119.x. [DOI] [PubMed] [Google Scholar]
- EHRENPREIS T., PERNOW B. On the occurrence of substance P in the rectosigmoid in Hirschsprung's disease. Acta Physiol Scand. 1953 Feb 28;27(4):380–388. doi: 10.1111/j.1748-1716.1953.tb00953.x. [DOI] [PubMed] [Google Scholar]
- GINZEL K. H. The action of lysergic acid diethylamide (LSD 25), its 2-brom derivative (BOL 148) and of 5-hydroxytryptamine (5-HT) on the peristaltic reflex of the guinea-pig ileum. J Physiol. 1957 Jul 11;137(2):62P–623. [PubMed] [Google Scholar]
- KOSTERLITZ H. W., ROBINSON J. A. Inhibition of the peristaltic reflex of the isolated guinea-pig ileum. J Physiol. 1957 Apr 30;136(2):249–262. doi: 10.1113/jphysiol.1957.sp005757. [DOI] [PMC free article] [PubMed] [Google Scholar]
- LEMBECK F. Untersuchungen über die Auslösung afferenter Impulse. Naunyn Schmiedebergs Arch Exp Pathol Pharmakol. 1957;230(1):1–9. [PubMed] [Google Scholar]
- Stephenson R. P. An outflow recorder useful for detecting small amounts of vasopressin. J Physiol. 1948 Mar 15;107(2):162–164. doi: 10.1113/jphysiol.1948.sp004259. [DOI] [PMC free article] [PubMed] [Google Scholar]