Abstract
Cooling the guinea-pig ileum to 19 to 26° abolished the emptying phase of the peristaltic reflex. The effects of cooling to 10° were usually reversible, but cooling to 5° for 3 to 8 hr. produced an irreversible decrease in or abolition of the emptying phase. 5-Hydroxytryptamine (5-HT) added in low concentrations to the fluid outside the intestine restored slight peristaltic activity after this activity had been abolished by cooling. If the peristalsis had been depressed but not abolished by cooling, 5-HT in the bath sometimes abolished it. 5-HT introduced into the lumen of the cooled gut regularly restored or increased peristaltic activity. This action was prevented by previous injection of 2-bromolysergic acid diethylamide into the lumen. It is suggested that, when introduced into the lumen, 5-HT may sensitize the sensory receptors in the mucosa of the cooled intestine. When applied outside, 5-HT may facilitate transmission at synapses involved in the peristaltic reflex arc, the excitability of which has been depressed by cooling.
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Selected References
These references are in PubMed. This may not be the complete list of references from this article.
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