Skip to main content

Some NLM-NCBI services and products are experiencing heavy traffic, which may affect performance and availability. We apologize for the inconvenience and appreciate your patience. For assistance, please contact our Help Desk at info@ncbi.nlm.nih.gov.

British Journal of Pharmacology and Chemotherapy logoLink to British Journal of Pharmacology and Chemotherapy
. 1958 Sep;13(3):266–270. doi: 10.1111/j.1476-5381.1958.tb00901.x

The effect of cooling and of 5-hydroxytryptamine on the peristaltic reflex of the isolated guinea-pig ileum

D Beleslin, V Varagić
PMCID: PMC1481778  PMID: 13584727

Abstract

Cooling the guinea-pig ileum to 19 to 26° abolished the emptying phase of the peristaltic reflex. The effects of cooling to 10° were usually reversible, but cooling to 5° for 3 to 8 hr. produced an irreversible decrease in or abolition of the emptying phase. 5-Hydroxytryptamine (5-HT) added in low concentrations to the fluid outside the intestine restored slight peristaltic activity after this activity had been abolished by cooling. If the peristalsis had been depressed but not abolished by cooling, 5-HT in the bath sometimes abolished it. 5-HT introduced into the lumen of the cooled gut regularly restored or increased peristaltic activity. This action was prevented by previous injection of 2-bromolysergic acid diethylamide into the lumen. It is suggested that, when introduced into the lumen, 5-HT may sensitize the sensory receptors in the mucosa of the cooled intestine. When applied outside, 5-HT may facilitate transmission at synapses involved in the peristaltic reflex arc, the excitability of which has been depressed by cooling.

Full text

PDF
266

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Ambache N. Interaction of drugs and the effect of cooling on the isolated mammalian intestine. J Physiol. 1946 Jan 15;104(3):266–287. doi: 10.1113/jphysiol.1946.sp004120. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. GINZEL K. H. The action of lysergic acid diethylamide (LSD 25), its 2-brom derivative (BOL 148) and of 5-hydroxytryptamine (5-HT) on the peristaltic reflex of the guinea-pig ileum. J Physiol. 1957 Jul 11;137(2):62P–623. [PubMed] [Google Scholar]
  3. KOSTERLITZ H. W., ROBINSON J. A. Inhibition of the peristaltic reflex of the isolated guinea-pig ileum. J Physiol. 1957 Apr 30;136(2):249–262. doi: 10.1113/jphysiol.1957.sp005757. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. PATON W. D. M., ZAIMIS E. J. The pharmacological actions of polymethylene bistrimethyl-ammonium salts. Br J Pharmacol Chemother. 1949 Dec;4(4):381–400. doi: 10.1111/j.1476-5381.1949.tb00565.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Stephenson R. P. An outflow recorder useful for detecting small amounts of vasopressin. J Physiol. 1948 Mar 15;107(2):162–164. doi: 10.1113/jphysiol.1948.sp004259. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from British Journal of Pharmacology and Chemotherapy are provided here courtesy of The British Pharmacological Society

RESOURCES