Abstract
Repeated subcutaneous injections of ganglionic blocking agents in cats were found to cause a supersensitivity towards adrenaline in the submaxillary gland and the nictitating membrane. The supersensitivity resembled that produced by preganglionic denervation, namely section of the chorda tympani in the case of the gland and of the cervical sympathetic trunk in the case of the membrane. The blocking compounds used were chlorisondamine chloride and hexamethonium. With the former, the sensitization could be obtained in the normally innervated structures. When hexamethonium was used, however, the effect on the gland could be produced only if the synapse had been made particularly susceptible to the blocking action of this agent; this was achieved by cross-suture experiments.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- EMMELIN N., HENRIKSSON K. G. Depressor activity of saliva after section of the chorda tympani. Acta Physiol Scand Suppl. 1953;111:75–82. [PubMed] [Google Scholar]
- EMMELIN N., JACOBSOHN D., MUREN A. Effects of prolonged administration of tropine and pilocarpine on the submaxillary gland of the cat. Acta Physiol Scand. 1951;24(2-3):128–143. doi: 10.1111/j.1748-1716.1951.tb00832.x. [DOI] [PubMed] [Google Scholar]
- EMMELIN N., MUREN A., STROMBLAD R. Effect of anastomosis between the hypoglossal and chorda-lingual nerves on the supersensitivity of the denervated submaxillary gland. Acta Physiol Scand. 1957 Nov 26;41(1):18–34. doi: 10.1111/j.1748-1716.1957.tb01507.x. [DOI] [PubMed] [Google Scholar]
- EMMELIN N., STROMBLAD B. C. Sensitization of the submaxillary gland above the level reached after section of the chorda tympani. Acta Physiol Scand. 1957 Mar 7;38(3-4):319–330. doi: 10.1111/j.1748-1716.1957.tb01395.x. [DOI] [PubMed] [Google Scholar]
- MUREN A. Gastric motor responses to adrenaline and noradrenaline after treatment with a parasympathicolytic agent. Acta Physiol Scand. 1957 Jun 8;39(2-3):188–194. doi: 10.1111/j.1748-1716.1957.tb01420.x. [DOI] [PubMed] [Google Scholar]
- NORDENFELT I., OHLIN P. Supersensitivity of salivary glands of rabbits. Acta Physiol Scand. 1957 Nov 26;41(1):12–17. doi: 10.1111/j.1748-1716.1957.tb01506.x. [DOI] [PubMed] [Google Scholar]