Abstract
The action of morphine (0.1 to 100 mg./kg.) on the cardiac slowing produced by stimulation of the right vagus nerve varied in the four species investigated. In the guinea-pig, morphine had no inhibitory effect and in the cat the effect was small, but in the rat and the rabbit stimulation of the vagus slowed the heart much less after administration of morphine than before. Further, in the last two species morphine delayed the onset of cardiac slowing. Nalorphine, which given alone had a slight morphine-like action, partly reversed the effect of morphine.
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Selected References
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- HEBB C. O., KONZETT H. The effect of certain analgesic drugs on synaptic transmission as observed in the perfused superior cervical ganglion of the cat. Q J Exp Physiol Cogn Med Sci. 1949 Nov;35(3):213–217. doi: 10.1113/expphysiol.1949.sp000950. [DOI] [PubMed] [Google Scholar]
- KOSTERLITZ H. W., KRAYER O., MATALLANA A. Studies on veratrum alkaloids, XXII. Periodic activity of the sino-auricular node of the denervated cat heart caused by veratramine. J Pharmacol Exp Ther. 1955 Apr;113(4):460–469. [PubMed] [Google Scholar]
- SCHAUMANN W. The paralysing action of morphine on the guinea-pig ileum. Br J Pharmacol Chemother. 1955 Dec;10(4):456–461. doi: 10.1111/j.1476-5381.1955.tb00105.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- TRENDELENBURG U. The action of morphine on the superior cervical ganglion and on the nictitating membrane of the cat. Br J Pharmacol Chemother. 1957 Mar;12(1):79–85. doi: 10.1111/j.1476-5381.1957.tb01366.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- WIKLER A. Sites and mechanisms of action of morphine and related drugs in the central nervous system. J Pharmacol Exp Ther. 1950 Dec;100(42):435–506. [PubMed] [Google Scholar]