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. 1959 Jun;14(2):284–302. doi: 10.1111/j.1476-5381.1959.tb01400.x

Pharmacology of methylpentynol and methylpentynol carbamate

E Marley
PMCID: PMC1481807  PMID: 13662590

Abstract

The pharmacology of methylpentynol and methylpentynol carbamate has been studied. The drugs depressed monosynaptic and polysynaptic reflexes, and exerted weak ganglion and neuromuscular blocking actions. They also produced transitory hypotension, and increase of aortic blood flow. Perfusion of the coronary arteries with these drugs led to slowing of the heart, diminished systolic amplitude, dysrhythmias, and increased coronary flow. Respiration was stimulated with small and depressed with larger doses of both drugs. The two compounds diminished the response of the isolated guinea-pig ileum to drugs acting directly on muscle or through ganglia. The effect of the two substances was likened to that of other central nervous system depressants, particularly to that of ethanol.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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