Skip to main content
NCBI home page
British Journal of Pharmacology and Chemotherapy logoLink to British Journal of Pharmacology and Chemotherapy
. 1959 Mar;14(1):5–8. doi: 10.1111/j.1476-5381.1959.tb00920.x

2-Hydroxyiminomethyl-n-methylpyridinium methanesulphonate and atropine in the treatment of severe organophosphate poisoning

D R Davies, A L Green, G L Willey
PMCID: PMC1481822  PMID: 13651571

Abstract

The soluble methanesulphonate of the oxime 2-hydroxyiminomethyl-N-methylpyridinium (P2S) has been used to treat animals poisoned with sarin or ethyl pyrophosphate. The effect of the size of the dose, and its time of administration in relation to poisoning, have been examined. This oxime is very efficient in conjunction with atropine when given either before or after poisoning. About 30 mg./kg. seems to be the optimum therapeutic dose of the methanesulphonate. The significance of this optimum is discussed in relation to the treatment of accidental poisoning by organophosphate insecticides in man.

Full text

PDF
5

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ASKEW B. M. Oximes and atropine in sarin poisoning. Br J Pharmacol Chemother. 1957 Sep;12(3):340–343. doi: 10.1111/j.1476-5381.1957.tb00145.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. DAVIES D. R., WILLEY G. L. The toxicity of 2-hydroxyiminomethyl-N-methylpyridinium methanesulphonate (P2S). Br J Pharmacol Chemother. 1958 Jun;13(2):202–206. doi: 10.1111/j.1476-5381.1958.tb00218.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. FOURNEL J. Action antidote de l'iodométhylate de l'alpha-pyridylaldcxime vis-à-vis des intoxications expérimentales provoquées par les insecticides organophosphorés. C R Seances Soc Biol Fil. 1957;151(7):1373–1377. [PubMed] [Google Scholar]
  4. GREEN A. L., SMITH H. J. The reactivation of cholinesterase inhibited with organophosphorus compounds. I. Reactivation by 2-oxoaldoximes. Biochem J. 1958 Jan;68(1):28–31. doi: 10.1042/bj0680028. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. HOBBIGER F. Protection against the lethal effects of organophosphates by pyridine-2-aldoxime methiodide. Br J Pharmacol Chemother. 1957 Dec;12(4):438–446. doi: 10.1111/j.1476-5381.1957.tb00162.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. KEWITZ H., NACHMANSOHN D., WILSON I. B. A specific antidote against lethal alkyl phosphate intoxication. II. Antidotal properties. Arch Biochem Biophys. 1956 Oct;64(2):456–465. doi: 10.1016/0003-9861(56)90288-0. [DOI] [PubMed] [Google Scholar]
  7. NAMBA T., HIRAKI K. PAM (pyridine-2-aldoxime methiodide) therapy for alkyl-phosphate poisoning. J Am Med Assoc. 1958 Apr 12;166(15):1834–1839. doi: 10.1001/jama.1958.02990150030007. [DOI] [PubMed] [Google Scholar]
  8. Thompson W. R. USE OF MOVING AVERAGES AND INTERPOLATION TO ESTIMATE MEDIAN-EFFECTIVE DOSE: I. Fundamental Formulas, Estimation of Error, and Relation to Other Methods. Bacteriol Rev. 1947 Jun;11(2):115–145. [PMC free article] [PubMed] [Google Scholar]
  9. WILLS J. H., KUNKEL A. M., BROWN R. V., GROBLEWSKI G. E. Pyridine-2-aldoxime methiodide and poisoning by anticholinesterases. Science. 1957 Apr 19;125(3251):743–744. doi: 10.1126/science.125.3251.743. [DOI] [PubMed] [Google Scholar]
  10. WILSON I. B., SONDHEIMER F. A specific antidote against lethal alkyl phosphate intoxication. V. Antidotal properties. Arch Biochem Biophys. 1957 Jul;69:468–474. doi: 10.1016/0003-9861(57)90511-8. [DOI] [PubMed] [Google Scholar]

Articles from British Journal of Pharmacology and Chemotherapy are provided here courtesy of The British Pharmacological Society

RESOURCES