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. 1959 Mar;14(1):48–58. doi: 10.1111/j.1476-5381.1959.tb00928.x

Some quantitative uses of drug antagonists

O Arunlakshana, H O Schild
PMCID: PMC1481829  PMID: 13651579

Abstract

Various applications of pAx measurements are discussed based on the hypothesis that drugs and drug antagonists compete for receptors according to the mass law. Examples are given illustrating the use of pAx measurements to identify agonists which act on the same receptors and to compare the receptors of different tissues. Tests of competitive and noncompetitive antagonism are considered in relation to the antagonisms acetylcholine-atropine, histamine-atropine and acetylcholine-cinchonidine. A new measure, pAh, is introduced to express the activity of unsurmountable antagonists.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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