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. 1958 Dec;13(4):498–500. doi: 10.1111/j.1476-5381.1958.tb00245.x

The difference in the metabolism of injected [14c]histamine in male and female rats

H Westling
PMCID: PMC1481867  PMID: 13618558

Abstract

[14C]Histamine was injected subcutaneously in rats. The urine was collected for 24 hr. and analysed for [14C]histamine and its various metabolites. It was found that male rats excreted less unchanged [14C]histamine than female ones, the difference between the sexes existing also when the animals were treated with aminoguanidine. The cause of the sexual difference appeared to be that the male rats had a larger capacity to methylate histamine.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. COOPER J. A., SCHAYER R. W. Metabolism of C14 histamine in man. J Appl Physiol. 1956 Nov;9(3):481–483. doi: 10.1152/jappl.1956.9.3.481. [DOI] [PubMed] [Google Scholar]
  2. DEBLEY V. G., HALEY T. J., LEITCH J. L. Endogenous histamine excretion in the rat as influenced by x-ray irradiation and compound 48/80. Am J Physiol. 1956 Nov;187(2):307–311. doi: 10.1152/ajplegacy.1956.187.2.307. [DOI] [PubMed] [Google Scholar]
  3. GUSTAFSSON B., KAHLSON G., ROSENGREN E. Biogenesis of histamine studied by its distribution and urinary excretion in germ free reared and not germ free rats fed a histamine free diet. Acta Physiol Scand. 1957 Dec 7;41(2-3):217–228. doi: 10.1111/j.1748-1716.1957.tb01522.x. [DOI] [PubMed] [Google Scholar]
  4. LINDELL S. E., SCHAYER R. W. The renal removal of injected [14C] histamine from the blood in dogs. Br J Pharmacol Chemother. 1958 Mar;13(1):44–51. doi: 10.1111/j.1476-5381.1958.tb00188.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. SCHAYER R. W., DAVIS K. J., SMILEY R. L. Evaluation of histamine release in rats by analysis of urine. Am J Physiol. 1955 Jun;181(3):484–486. doi: 10.1152/ajplegacy.1955.181.3.484. [DOI] [PubMed] [Google Scholar]
  6. SCHAYER R. W., KENNEDY J., SMILEY R. L. Studies on histamine-metabolizing enzymes in intact animals. II. J Biol Chem. 1953 Dec;205(2):739–748. [PubMed] [Google Scholar]
  7. SCHAYER R. W. Studies on histaminemetabolizing enzymes in intact animals. J Biol Chem. 1953 Aug;203(2):787–793. [PubMed] [Google Scholar]
  8. SCHULER W. Zur Hemmung der Diaminooxydase (Histaminase). Experientia. 1952 Jun 15;8(6):230–232. doi: 10.1007/BF02170726. [DOI] [PubMed] [Google Scholar]
  9. WILSON C. W. Factors influencing the urinary excretion of histamine in the rat. J Physiol. 1954 Oct 28;126(1):141–154. doi: 10.1113/jphysiol.1954.sp005199. [DOI] [PMC free article] [PubMed] [Google Scholar]

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