Abstract
In cats under chloralose anaesthesia the reflex fall of blood pressure and heart rate caused by injection of veratrine, amidines, diphenhydramine, or ethyl acetoacetate was accompanied by a fall in cardiac output. After veratrine and amidines there was a fall in mean pulmonary arterial pressure and after veratrine no significant change in pulmonary vascular resistance. After diphenhydramine and ethyl acetoacetate there was a rise in mean pulmonary arterial pressure and after diphenhydramine an increase in pulmonary vascular resistance. The effects of veratrine and amidines, but not those of diphenhydramine and ethyl acetoacetate, were abolished by section of the vagi. The main change leading to the fall of cardiac output after amidines was bradycardia.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- BARER G. R., KOTTEGODA S. R. Changes in heart rate and blood pressure of the cat in response to increased pressure in the right side of the heart. J Physiol. 1958 Aug 29;143(1):1–10. doi: 10.1113/jphysiol.1958.sp006040. [DOI] [PMC free article] [PubMed] [Google Scholar]
- CARLILL S. D., DUKE H. B. Pulmonary vascular changes in response to variations in left auricular pressure. J Physiol. 1956 Aug 28;133(2):275–286. doi: 10.1113/jphysiol.1956.sp005585. [DOI] [PMC free article] [PubMed] [Google Scholar]
- DAWES G. S., COMROE J. H., Jr Chemoreflexes from the heart and lungs. Physiol Rev. 1954 Apr;34(2):167–201. doi: 10.1152/physrev.1954.34.2.167. [DOI] [PubMed] [Google Scholar]
- DAWES G. S., MOTT J. C., WIDDICOMBE J. G. Respiratory and cardiovascular reflexes from the heart and lungs. J Physiol. 1951 Nov 28;115(3):258–291. doi: 10.1113/jphysiol.1951.sp004670. [DOI] [PMC free article] [PubMed] [Google Scholar]
- DE DALY I B., DE DALY M B. Observations on the changes in resistance of the pulmonary vascular bed in response to stimulation of the carotid sinus baroreceptors in the dog. J Physiol. 1957 Aug 6;137(3):427–435. doi: 10.1113/jphysiol.1957.sp005824. [DOI] [PMC free article] [PubMed] [Google Scholar]
- GINZEL K. H., KOTTEGODA S. R. A study of the vascular actions of 5-hydroxytryptamine, tryptamine, adrenaline and noradrenaline. Q J Exp Physiol Cogn Med Sci. 1953;38(4):225–231. doi: 10.1113/expphysiol.1953.sp001033. [DOI] [PubMed] [Google Scholar]