Abstract
Methods of testing new drugs for anti-Parkinson activity are briefly reviewed. The production in animals of Parkinson-like effects by Tremorine (1,4-dipyrrolidin-1'-ylbut-2-yne), and the inhibition of these effects in mice by a number of tropine derivatives, are described. No correlation was found between the activity against tremor and the anticholinergic, antihistaminic or local anaesthetic properties of the compounds.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- ADAM H. M., HARDWICK D. C., SPENCER K. E. Assay of histamine on the isolated guinea-pig intestine by the method of superfusion. Br J Pharmacol Chemother. 1954 Sep;9(3):360–366. doi: 10.1111/j.1476-5381.1954.tb01693.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- BOVET D., LONGO V. G. The action on nicotine-induced tremors of substances effective in Parkinsonism. J Pharmacol Exp Ther. 1951 May;102(1):22–30. [PubMed] [Google Scholar]
- CAHEN R. L., LYNES T. E. Nicotinolytic drugs. I. Drugs inhibiting nicotine-induced tremors. J Pharmacol Exp Ther. 1951 Sep;103(1):44–53. [PubMed] [Google Scholar]
- CAHEN R. L., THOMAS J. M., TVEDE K. M. Nicotinolytic drugs. II. Action of adrenergic blocking agents on nicotine-induced tremors. J Pharmacol Exp Ther. 1953 Apr;107(4):424–436. [PubMed] [Google Scholar]
- CRITCHLEY M. Drug treatment of parkinsonism. Br Med J. 1958 Nov 15;2(5106):1214–1215. doi: 10.1136/bmj.2.5106.1214. [DOI] [PMC free article] [PubMed] [Google Scholar]
- DOSHAY L. J. Five-year study of benztropine (cogentin) methanesulfonate; outcome in three hundred two cases of paralysis agitans. J Am Med Assoc. 1956 Nov 10;162(11):1031–1034. doi: 10.1001/jama.1956.02970280011004. [DOI] [PubMed] [Google Scholar]
- EVERETT G. M. Tremor produced by drugs. Nature. 1956 Jun 30;177(4522):1238–1238. doi: 10.1038/1771238a0. [DOI] [PubMed] [Google Scholar]
- FROMMEL E. La pharmacodynamie de la médication antiparkinsonienne. Presse Med. 1958 Nov 8;66(78):1745–1746. [PubMed] [Google Scholar]
- JENKNER F. L., WARD A., Jr Bulbar reticular formation and tremor. AMA Arch Neurol Psychiatry. 1953 Oct;70(4):489–502. [PubMed] [Google Scholar]
- TRAUTNER E. M., GERSHON S. Use of tremorine for screening anti-parkinsonian drugs. Nature. 1959 May 23;183(4673):1462–1463. doi: 10.1038/1831462a0. [DOI] [PubMed] [Google Scholar]
- TRAUTNER E. M., NOACK C. H. Tigloidine as a substitute for atropine in the treatment of Parkinsonism. Med J Aust. 1951 May 26;1(21):751–754. doi: 10.5694/j.1326-5377.1951.tb56491.x. [DOI] [PubMed] [Google Scholar]
- UNNA K. R., VERNIER V. G. The experimental evaluation of antiparkinsonian compounds. Ann N Y Acad Sci. 1956 Nov 16;64(4):690–704. doi: 10.1111/j.1749-6632.1956.tb36841.x. [DOI] [PubMed] [Google Scholar]