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British Journal of Pharmacology and Chemotherapy logoLink to British Journal of Pharmacology and Chemotherapy
. 1960 Jun;15(2):351–355. doi: 10.1111/j.1476-5381.1960.tb01255.x

The effect of enzyme inhibitors on histamine catabolism in man

S E Lindell, Karen Nilsson, B-E Roos, H Westling
PMCID: PMC1481924  PMID: 14417081

Abstract

The catabolism of histamine was studied in three female psychiatric patients by analysis of the [14C]-labelled metabolic products occurring in the urine after a subcutaneous injection of [14C]histamine. Each patient was studied before and during treatment with aminoguanidine or iproniazid.

Without treatment the patients had a normal histamine catabolism. Aminoguanidine and iproniazid inhibited the oxidation of histamine to imidazoleacetic acid; iproniazid produed a 50% inhibition of the oxidation of methylhistamine to methylimidazoleacetic acid. After iproniazid a large proportion of the injected [C14]histamine was excreted as methyl [14C]histamine.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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