Abstract
The effect of temperature on the direct twitch response of the normal and denervated rat diaphragm, and the sensitivity of the contractural response of the denervated muscle to acetylcholine, suxamethonium, decamethonium, and potassium salts, was studied. Cooling the normal diaphragm from 39 to 20° increased the size of the direct twitch, but below this temperature the twitch response of the muscle was progressively depressed. The denervated muscle twitch was, by contrast, maximal at 39° and decreases as the temperature was lowered. This property of the denervated muscle first appeared about the third day after denervation. The contractural response of the denervated diaphragm to applied acetylcholine was enhanced by cooling, while the response to potassium salts was depressed. The depression of the contracture induced by potassium followed closely the depression of the direct muscle twitch of the denervated muscle over the same temperature range.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- ANDJUS R. K., SMITH A. U. Reanimation of adult rats from body temperatures between 0 and + 2 degrees C. J Physiol. 1955 Jun 28;128(3):446–472. doi: 10.1113/jphysiol.1955.sp005318. [DOI] [PMC free article] [PubMed] [Google Scholar]
- AXELSSON J., THESLEFF S. A study of supersensitivity in denervated mammalian skeletal muscle. J Physiol. 1959 Jun 23;147(1):178–193. doi: 10.1113/jphysiol.1959.sp006233. [DOI] [PMC free article] [PubMed] [Google Scholar]
- BIGLAND B., GOETZEE B., MACLAGAN J., ZAIMIS E. The effect of lowered muscle temperature on the action of neuromuscular blocking drugs. J Physiol. 1958 May 28;141(3):425–434. doi: 10.1113/jphysiol.1958.sp005986. [DOI] [PMC free article] [PubMed] [Google Scholar]
- DOUDOUMOPOULOS A. N., CHATFIELD P. O. Effects of temperature on function of mammalian (rat) muscle. Am J Physiol. 1959 Jun;196(6):1197–1199. doi: 10.1152/ajplegacy.1959.196.6.1197. [DOI] [PubMed] [Google Scholar]
- Dale H. H., Gaddum J. H. Reactions of denervated voluntary muscle, and their bearing on the mode of action of parasympathetic and related nerves. J Physiol. 1930 Sep 18;70(2):109–144. doi: 10.1113/jphysiol.1930.sp002682. [DOI] [PMC free article] [PubMed] [Google Scholar]
- HAJDU S., KNOX J. A. C., McDOWALL R. J. S. Potassium and neuromuscular transmission. J Physiol. 1950 Oct 16;111(3-4):382–387. doi: 10.1113/jphysiol.1950.sp004488. [DOI] [PMC free article] [PubMed] [Google Scholar]
- HOLMES P. E. B., JENDEN D. J., TAYLOR D. B. The analysis of the mode of action of curare on neuromuscular transmission; the effect of temperature changes. J Pharmacol Exp Ther. 1951 Dec;103(4):382–402. [PubMed] [Google Scholar]
- JEFFERSON N. C., OGAWA T., NECHELES H. Trophic effects in the absence of respiratory function of the phrenic nerve. Am J Physiol. 1958 Jun;193(3):563–566. doi: 10.1152/ajplegacy.1958.193.3.563. [DOI] [PubMed] [Google Scholar]
- JEFFERSON N. C., OGAWA T., TOMAN J., SCRUGGS W., NECHELES H. Tropic maintenance of the diaphragm by various nerves. Am J Physiol. 1959 Sep;197:511–514. doi: 10.1152/ajplegacy.1959.197.3.511. [DOI] [PubMed] [Google Scholar]
- JEFFERSON N. C., PHILLIPS C. W., NECHELES H. Left phreno-phrenic anastomosis. J Appl Physiol. 1950 Sep;3(3):161–163. doi: 10.1152/jappl.1950.3.3.161. [DOI] [PubMed] [Google Scholar]
- MACLAGAN J., ZAIMIS E. The effect of muscle temperature on twitch and tetanus in the cat. J Physiol. 1957 Aug 6;137(3):89–90P. [PubMed] [Google Scholar]
- ZAIMIS E. Factors influencing the action of neuromuscular blocking substances. Lect Sci Basis Med. 1956;VOL:208–216. [PubMed] [Google Scholar]