Abstract
Previous observations have shown that the effects of sympathetic stimulation and of tyramine were absent in the organs of animals treated with reserpine, but that they were restored by an infusion of noradrenaline. Observations are described showing that an infusion of adrenaline did not restore the pressor action of tyramine in the cat or in the rat, but that in the rat the pressor action was restored by an infusion of dopamine, or of (—)-dopa, or of m-tyrosine,or of phenylalanine. Observations are also described showing that the effect of postganglionic stimulation of the fibres to the nictitating membrane and to the iris was restored by an infusion of dopamine or of (—)-dopa; it was restored less well by an infusion of noradrenaline. An infusion of noradrenaline did not restore the action of tyramine on the denervated iris or on the denervated vessels of the cat's foreleg. An infusion of noradrenaline appeared to increase the effect of sympathetic stimulation of the hypogastric nerves to the uterus of the virgin cat about as much as an infusion of adrenaline. An infusion of noradrenaline restored the constrictor action of nicotine on the perfused vessels of the rabbit ear.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- BLASCHKO H. The development of current concepts of catecholamine formation. Pharmacol Rev. 1959 Jun;11(2 Pt 2):307–316. [PubMed] [Google Scholar]
- MUSCHOLL E., VOGT M. The concentration of adrenaline in the plasma of rabbits treated with reserpine. Br J Pharmacol Chemother. 1957 Dec;12(4):532–535. doi: 10.1111/j.1476-5381.1957.tb00178.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- RAAB W., GIGEE W. Specific avidity of the heart muscle to absorb and store epinephrine and norepinephrine. Circ Res. 1955 Nov;3(6):553–558. doi: 10.1161/01.res.3.6.553. [DOI] [PubMed] [Google Scholar]
- Stephenson R. P. An outflow recorder useful for detecting small amounts of vasopressin. J Physiol. 1948 Mar 15;107(2):162–164. doi: 10.1113/jphysiol.1948.sp004259. [DOI] [PMC free article] [PubMed] [Google Scholar]
- VON EULER U. S. The catechol amine content of various organs of the cat after injections and infusions of adrenaline and Noradrenaline. Circ Res. 1956 Nov;4(6):647–652. doi: 10.1161/01.res.4.6.647. [DOI] [PubMed] [Google Scholar]