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. 1960 Mar;15(1):71–81. doi: 10.1111/j.1476-5381.1960.tb01212.x

The neuromuscular blocking properties of a series of bis-quaternary tropeïnes

C G Haining, R G Johnston, J M Smith
PMCID: PMC1481991  PMID: 14398886

Abstract

Linkage of two tropine esters through their nitrogen atoms by the chain -[CH2]m-O-CO-[CH2]n-CO-O-[CH2]m-, in which m was 2 or 3 and n varied from 0 to 6, gave compounds which produced neuromuscular block without depolarization. Reversibility be neostigmine was confirmed for a few compounds. Potency was found to depend upon the tropine ester employed and upon the values of n and m. Short duration and hypotensive properties were favoured by the higher values of n. The duration of action of the compound based on the phenylacetic acid ester of tropine, in which n=4 and m=2, varied considerably in different species. Epimerization, in which the relative positions of the methyl group and the linking chain on the quaternary tropane nitrogen atom were reversed, did not produce subtances having more favourable properties than those possessed by the unepimerized compounds.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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