Abstract
Thalidomide (α-phthalimidoglutarimide, “Distaval,” “Contergan”) is a new sedative hypnotic drug which produces no toxic effects when administered orally to animals in massive doses. This lack of toxicity may be due to limited absorption. The drug has a quietening effect on the central nervous system, reducing the voluntary activity of laboratory animals and promoting sleep. Unlike the barbiturate drugs it does not cause an initial excitation in mice, incoordination or narcosis. It potentiates the actions of other central nervous system depressants, in particular the barbiturates. Its sedative effects are counteracted by central nervous system stimulants. It has no deleterious side effects and does not affect the heart, respiration or autonomic nervous system.
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Selected References
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- BIANCHI C., FRANCESCHINI J. Experimental observations on Haffner's method for testing analgesic drugs. Br J Pharmacol Chemother. 1954 Sep;9(3):280–284. doi: 10.1111/j.1476-5381.1954.tb01681.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- BRYANT H. H., FELTON L. C., KRANTZ J. C., Jr A pharmacologic and toxicologic study of a new series of antispasmodic compounds with special reference to structure and pharmacologic activity. J Pharmacol Exp Ther. 1957 Oct;121(2):210–224. [PubMed] [Google Scholar]
- BURLEY D. M., DENNISON T. C., HARRISON W. Clinical experience with a new sedative drug. Practitioner. 1959 Jul;183:57–61. [PubMed] [Google Scholar]
- DEWS P. B. The measurement of the influence of drugs on voluntary activity in mice. Br J Pharmacol Chemother. 1953 Mar;8(1):46–48. doi: 10.1111/j.1476-5381.1953.tb00749.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Dodds E. C., Lawson W., Simpson S. A., Williams P. C. Testing diphenylethylamine compounds for analgesic action. J Physiol. 1945 Jun 29;104(1):47–51. doi: 10.1113/jphysiol.1945.sp004105. [DOI] [PMC free article] [PubMed] [Google Scholar]
- FINCATO M. Effetto potenziante oeiia imide dell'ac. N-ftalil-glutammico (FGI) sul sonno da barbiturici. Boll Soc Ital Biol Sper. 1957 Jun;33(6):872–874. [PubMed] [Google Scholar]
- FRIEDELL M. T. Effect of tranquilizing agents on radioactive iodine uptake in the thyroid gland. J Am Med Assoc. 1958 Jun 21;167(8):983–984. doi: 10.1001/jama.1958.72990250008009a. [DOI] [PubMed] [Google Scholar]
- GROSS F., TRIPOD J., MEIER R. Zur pharmakologischen Charakterisierung des Schlafmittels Doriden. Schweiz Med Wochenschr. 1955 Mar 26;85(13):305–309. [PubMed] [Google Scholar]
- JUNG H. Klinische Erfahrungen mit einem neuen Sedativum. Arzneimittelforschung. 1956 Aug;6(8):430–432. [PubMed] [Google Scholar]
- KELLER H., KUNZ W., MUCKTER H. N-Phthalyl-glutaminsäure-imid; experimentelle Untersuchungen an einem neuen synthetischen Produkt mit sedativen Eigenschaften. Arzneimittelforschung. 1956 Aug;6(8):426–430. [PubMed] [Google Scholar]
- KOPMANN E., HUGHES F. W. Effects of glutamate on the potentiating action of certain ataraxics. Proc Soc Exp Biol Med. 1958 Jan;97(1):83–85. doi: 10.3181/00379727-97-23651. [DOI] [PubMed] [Google Scholar]
- KRAUSHAAR A. Zur Wirkungsanalyse analgetischer Substanzen. Arzneimittelforschung. 1953 May;3(5):247–251. [PubMed] [Google Scholar]
- MURDOCH J. M., CAMPBELL G. D. Antithyroid activity of N-phthalyl glutamic acid imide (K17). Br Med J. 1958 Jan 11;1(5062):84–85. doi: 10.1136/bmj.1.5062.84. [DOI] [PMC free article] [PubMed] [Google Scholar]
- STARK G. Klinische Erfahrungen mit dem Sedativum K 17 in der Lungenheilstätte und der allgemeinen Praxis. Praxis. 1956 Oct 18;45(42):966–968. [PubMed] [Google Scholar]