Skip to main content
British Journal of Pharmacology and Chemotherapy logoLink to British Journal of Pharmacology and Chemotherapy
. 1961 Jun;16(3):315–319. doi: 10.1111/j.1476-5381.1961.tb01090.x

Supersensitivity of salivary glands following treatment with bretylium or guanethidine

N Emmelin, J Engström
PMCID: PMC1482020  PMID: 13726638

Abstract

The sensitivity of the submaxillary glands to noradrenaline was estimated once a week in cats anaesthetized with hexobarbitone. Daily subcutaneous injections of bretylium or guanethidine were found to produce a supersensitivity of the glands, similar to that caused by extirpation of the superior cervical ganglion.

Full text

PDF
315

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BOURA A. L., COPP F. C., DUNCOMBE W. G., GREEN A. F., McCOUBREY A. The selective accumulation of bretylium in sympathetic ganglia and their postganglionic nerves. Br J Pharmacol Chemother. 1960 Jun;15:265–270. doi: 10.1111/j.1476-5381.1960.tb01242.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. BOURA A. L., GREEN A. F., McCOUBREY A., LAURENCE D. R., MOULTON R., ROSENHEIM M. L. Darenthin: hypotensive agent of new type. Lancet. 1959 Jul 11;2(7089):17–21. [PubMed] [Google Scholar]
  3. BOURA A. L., GREEN A. F. The actions of bretylium: adrenergic neurone blocking and other effects. Br J Pharmacol Chemother. 1959 Dec;14:536–548. doi: 10.1111/j.1476-5381.1959.tb00961.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. BURN J. H., RAND M. J. Noradrenaline in artery walls and its dispersal by reserpine. Br Med J. 1958 Apr 19;1(5076):903–908. doi: 10.1136/bmj.1.5076.903. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. BURN J. H., RAND M. J. The action of sympathomimetic amines in animals treated with reserpine. J Physiol. 1958 Dec 4;144(2):314–336. doi: 10.1113/jphysiol.1958.sp006104. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. BURN J. H., RAND M. J. The cause of the supersensitivity of smooth muscle to noradrenaline after sympathetic degeneration. J Physiol. 1959 Jun 23;147(1):135–143. doi: 10.1113/jphysiol.1959.sp006228. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. EMMELIN N., ENGSTROM J. Effect of sympathetic denervation on the sensitivity of the submaxillary gland to stimulating agents. J Physiol. 1960 Aug;153:9–16. doi: 10.1113/jphysiol.1960.sp006515. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. EMMELIN N., MUREN A. The sensitivity of submaxillary glands to chemical agents studied in cats under various conditions over long periods. Acta Physiol Scand. 1952 Sep 10;26(2-3):221–231. doi: 10.1111/j.1748-1716.1952.tb00905.x. [DOI] [PubMed] [Google Scholar]
  9. EMMELIN N. Supersensitivity following "pharmacological denervation". Pharmacol Rev. 1961 Mar;13:17–37. [PubMed] [Google Scholar]
  10. MAXWELL R. A., MULL R. P., PLUMMER A. J. [2-Octahydro-1-azocinyl)-ethyl]-guanidine sulfate (CIBA 5864-SU), a new synthetic antithypertensive agents]. Experientia. 1959 Jul 15;15:267–267. doi: 10.1007/BF02158076. [DOI] [PubMed] [Google Scholar]
  11. TRENDELENBURG U., GRAVENSTEIN J. S. Effect of reserpine pretreatment on stimulation of the accelerans nerve of the dog. Science. 1958 Oct 17;128(3329):901–903. doi: 10.1126/science.128.3329.901-a. [DOI] [PubMed] [Google Scholar]
  12. VERNIKOS-DANELLIS J., ZAIMIS E. Some pharmacological actions of bretylium and guanethidine. Lancet. 1960 Oct 8;2(7154):787–788. doi: 10.1016/s0140-6736(60)91856-0. [DOI] [PubMed] [Google Scholar]

Articles from British Journal of Pharmacology and Chemotherapy are provided here courtesy of The British Pharmacological Society

RESOURCES