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British Journal of Pharmacology and Chemotherapy logoLink to British Journal of Pharmacology and Chemotherapy
. 1961 Oct;17(2):267–275. doi: 10.1111/j.1476-5381.1961.tb01287.x

Effect of reserpine on growth and sexual development of chickens

P Hagen, A C Wallace
PMCID: PMC1482040  PMID: 13903592

Abstract

One-month-old male chickens were given injections of 1 mg, 2 mg and 4 mg/kg of reserpine. The injections were repeated at weekly intervals for three months. The chickens receiving reserpine grew at half the rate of untreated control chickens and failed to grow combs. At 4 months of age the testes of reserpine-treated chickens were only about one-tenth the weight of the testes of the control chickens and histologically they showed extreme hypoplasia of the seminiferous tubules. Two large doses of reserpine one month apart could cause atrophy of the testes of adult roosters.

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Selected References

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  1. BRIGGS F. N., MUNSON P. L., WELLS H. The inhibitory effect of reserpine on ACTH secretion in response to stressful stimuli. Endocrinology. 1956 Nov;59(5):571–579. doi: 10.1210/endo-59-5-571. [DOI] [PubMed] [Google Scholar]
  2. BURACK W. R., WEINER N., HAGEN P. B. The effect of reserpine on the catecholamine and adenine nucleotide contents of adrenal gland. J Pharmacol Exp Ther. 1960 Nov;130:245–250. [PubMed] [Google Scholar]
  3. Emmens C. W. The effect of prolonged dosage with oestrogens on the adult brown leghorn cock. J Physiol. 1939 Apr 14;95(3):379–392. doi: 10.1113/jphysiol.1939.sp003735. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. HOLZBAUER M., VOGT M. Depression by reserpine of the noradrenaline concentration in the hypothalamus of the cat. J Neurochem. 1956 May;1(1):8–11. doi: 10.1111/j.1471-4159.1956.tb12048.x. [DOI] [PubMed] [Google Scholar]
  5. MOON R. C., TURNER C. W. Effect of reserpine on oxytocin and lactogen discharge in lactating rats. Proc Soc Exp Biol Med. 1959 Jun;101(2):332–335. doi: 10.3181/00379727-101-24929. [DOI] [PubMed] [Google Scholar]
  6. MOON R. C., TURNER C. W. Effect of reserpine on thyroid activity in rats. Proc Soc Exp Biol Med. 1959 Apr;100(4):679–681. doi: 10.3181/00379727-100-24742. [DOI] [PubMed] [Google Scholar]
  7. PAASONEN M. K., VOGT M. The effect of drugs on the amounts of substance P and 5-hydroxytryptamine in mammalian brain. J Physiol. 1956 Mar 28;131(3):617–626. doi: 10.1113/jphysiol.1956.sp005486. [DOI] [PMC free article] [PubMed] [Google Scholar]

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