Abstract
Homogenates were prepared of the mucous membrane of the small intestine from dogs previously treated with high doses of reserpine. The granular material sedimented from these homogenates was centrifuged over a density gradient. The dense fraction usually rich in adenosinetriphosphate and 5-hydroxytryptamine contained little amine and no nucleotide; on the other hand, the less dense material, believed to consist mainly of mitochondria, contained amounts of adenosinetriphosphate similar to those found in animals not treated with reserpine.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- BAKER R. V. Mitochondria and storage granules for 5-hydroxytryptamine. J Physiol. 1959 Mar 12;145(3):473–481. doi: 10.1113/jphysiol.1959.sp006155. [DOI] [PMC free article] [PubMed] [Google Scholar]
- BLASCHKO H. The development of current concepts of catecholamine formation. Pharmacol Rev. 1959 Jun;11(2 Pt 2):307–316. [PubMed] [Google Scholar]
- BORN G. V., INGRAM G. I., STACEY R. S. The relationship between 5-hydroxytryptamine and adenosine triphosphate in blood platelets. Br J Pharmacol Chemother. 1958 Mar;13(1):62–64. doi: 10.1111/j.1476-5381.1958.tb00191.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- BURACK W. R., WEINER N., HAGEN P. B. The effect of reserpine on the catecholamine and adenine nucleotide contents of adrenal gland. J Pharmacol Exp Ther. 1960 Nov;130:245–250. [PubMed] [Google Scholar]
- HILLARP N. A. Effect of reserpine on the nucleotide and catecholamine content of the denervated adrenal medulla of the rat. Nature. 1960 Sep 17;187:1032–1032. doi: 10.1038/1871032a0. [DOI] [PubMed] [Google Scholar]
- HOLTON P. The liberation of adenosine triphosphate on antidromic stimulation of sensory nerves. J Physiol. 1959 Mar 12;145(3):494–504. doi: 10.1113/jphysiol.1959.sp006157. [DOI] [PMC free article] [PubMed] [Google Scholar]
- PRUSOFF W. H. The distribution of 5-hydroxytryptamine and adenosinetriphosphate in cytoplasmic particles of the dog's small intestine. Br J Pharmacol Chemother. 1960 Dec;15:520–524. doi: 10.1111/j.1476-5381.1960.tb00274.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- SCHUMANN H. J. Die Wirkung von Insulin und Reserpin auf den Adrenalin- und ATP-Gehalt der chromaffinen Granula des Nebennierenmarks. Naunyn Schmiedebergs Arch Exp Pathol Pharmakol. 1958;233(3):237–249. [PubMed] [Google Scholar]
- VANE J. R. A sensitive method for the assay of 5-hydroxytryptamine. Br J Pharmacol Chemother. 1957 Sep;12(3):344–349. doi: 10.1111/j.1476-5381.1957.tb00146.x. [DOI] [PMC free article] [PubMed] [Google Scholar]