Abstract
A study has been made of the toxicology and pharmacology of gadolinium and samarium chlorides. The symptoms of acute toxicity following intraperitoneal injection are described. The chronic oral ingestion of both chemicals for 12 weeks produced no effects on growth or the blood picture, and only the male rats receiving gadolinium chloride showed liver damage. The pharmacological responses to both chemicals were mainly depressant on all systems studied, and death was associated with cardiovascular collapse coupled with respiratory paralysis. The greatest damage seen was on abraded skin, where non-healing ulcers were produced by both chemicals, whereas irritation of intact skin and ocular tissues was only transient in nature.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- DURBIN P. W., WILLIAMS M. H., GEE M., NEWMAN R. H., HAMILTON J. G. Metabolism of the lanthanons in the rat. Proc Soc Exp Biol Med. 1956 Jan;91(1):78–85. doi: 10.3181/00379727-91-22175. [DOI] [PubMed] [Google Scholar]
- KYKER G. C., CRESS E. A. Acute toxicity of yttrium, lanthanum, and other rare earths. AMA Arch Ind Health. 1957 Dec;16(6):475–479. [PubMed] [Google Scholar]
- SHIPLEY R. E., WILSON C. An improved recording rotameter. Proc Soc Exp Biol Med. 1951 Dec;78(3):724–728. doi: 10.3181/00379727-78-19196. [DOI] [PubMed] [Google Scholar]