Abstract
In cats, 24 hr after the administration of 1 mg/kg of reserpine, it was found that (a) the heart is in failure; (b) the sensitivity of the peripheral vessels to adrenaline, noradrenaline and isoprenaline, administered intravenously or close-arterially, is decreased; (c) any blood pressure changes are, as a rule, secondary to changes in heart contraction; and (d) the peripheral blood flow passively follows the blood pressure changes. Furthermore, any improvement of the circulation at this stage was found to be almost exclusively the result of an amelioration in the force of cardiac contraction.
Full text
PDF
Images in this article
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- AXELROD J., TOMCHICK R. Increased rate of metabolism of epinephrine and norepinephrine by sympathomimetic amines. J Pharmacol Exp Ther. 1960 Dec;130:367–369. [PubMed] [Google Scholar]
- BAY E., COTTEN M. D. Direct measurement of changes in cardiac contractile force; relationship of such measurements to stroke work, isometric pressure gradient and other parameters of cardiac function. Am J Physiol. 1956 Sep;187(1):122–134. doi: 10.1152/ajplegacy.1956.187.1.122. [DOI] [PubMed] [Google Scholar]
- BURN J. H., RAND M. J. The action of sympathomimetic amines in animals treated with reserpine. J Physiol. 1958 Dec 4;144(2):314–336. doi: 10.1113/jphysiol.1958.sp006104. [DOI] [PMC free article] [PubMed] [Google Scholar]
- HILTON S. M. Experiments on the post contraction hyperaemia of skeletal muscle. J Physiol. 1953 Apr 28;120(1-2):230–245. doi: 10.1113/jphysiol.1953.sp004888. [DOI] [PMC free article] [PubMed] [Google Scholar]
- MARLEY E., PARE C. M. Cardiac failure with reserpine. Br Med J. 1956 Feb 4;1(4961):267–269. doi: 10.1136/bmj.1.4961.267. [DOI] [PMC free article] [PubMed] [Google Scholar]
- PERERA G. A. Edema and congestive failure related to administration of Rauwolfia serpentina. J Am Med Assoc. 1955 Oct 1;159(5):439–439. [PubMed] [Google Scholar]
- ZAIMIS E. Reserpine-induced circulatory failure. Nature. 1961 Nov 11;192:521–523. doi: 10.1038/192521a0. [DOI] [PubMed] [Google Scholar]