Abstract
The action of certain substances on the release of oxytocin has been studied in unanaesthetized lactating rats. The release of oxytocin has been assessed by the increase in weight after suckling of rats separated overnight from the mother. A large variety of substances appear to block the release of oxytocin. These include pentolinium, atropine and chlorpromazine. Adrenaline and noradrenaline also cause a block in the release of oxytocin, and it is suggested that adrenaline blocks the central release of oxytocin as well as blocking its peripheral action. Reserpine and oestradiol in the doses administered did not block the release of oxytocin. Block also occurred after the ingestion of water, ethanol and normal saline, an effect which may be produced indirectly by impulses from the gastro-intestinal tract.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- ABRAHAMS V. C., PICKFORD M. Simultaneous observations on the rate of urine flow and spontaneous uterine movements in the dog, and their relationship to posterior lobe activity. J Physiol. 1954 Nov 29;126(2):329–346. doi: 10.1113/jphysiol.1954.sp005213. [DOI] [PMC free article] [PubMed] [Google Scholar]
- BISSET G. W., WALKER J. M. The effects of nicotine, hexamethonium and ethanol on the secretion of the antidiuretic and oxytocic hormones of the rat. Br J Pharmacol Chemother. 1957 Dec;12(4):461–467. doi: 10.1111/j.1476-5381.1957.tb00166.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- CROSS B. A. Suckling antidiuresis in rabbits. J Physiol. 1951 Aug;114(4):447–453. doi: 10.1113/jphysiol.1951.sp004635. [DOI] [PMC free article] [PubMed] [Google Scholar]
- CROSS B. A. Sympathetico-adrenal inhibition of the neurohypophysial milk-ejection mechanism. J Endocrinol. 1953 Jan;9(1):7–18. [PubMed] [Google Scholar]
- DICKER S. E. The effects of methylpentynol on ethanol drinking and on water metabolism in rats. J Physiol. 1958 Nov 10;144(1):138–147. doi: 10.1113/jphysiol.1958.sp006091. [DOI] [PMC free article] [PubMed] [Google Scholar]
- GAUNT R., RENZI A. A., ANTONCHAK N., MILLER G. J., GILMAN M. Endocrine aspects of the pharmacology of reserpine. Ann N Y Acad Sci. 1954 Apr 30;59(1):22–35. doi: 10.1111/j.1749-6632.1954.tb45915.x. [DOI] [PubMed] [Google Scholar]
- GROSVENOR C. E., TURNER C. W. Evidence for adrenergic and cholinergic components in milk let-down reflex in lactating rat. Proc Soc Exp Biol Med. 1957 Aug-Sep;95(4):719–722. doi: 10.3181/00379727-95-23342. [DOI] [PubMed] [Google Scholar]
- MOON R. C., TURNER C. W. Effect of reserpine on oxytocin and lactogen discharge in lactating rats. Proc Soc Exp Biol Med. 1959 Jun;101(2):332–335. doi: 10.3181/00379727-101-24929. [DOI] [PubMed] [Google Scholar]
- PEETERS G., STORMORKEN H., VANSCHOUBROEK F. The effect of different stimuli on milk ejection and diuresis in the lactating cow. J Endocrinol. 1960 Apr;20:163–172. doi: 10.1677/joe.0.0200163. [DOI] [PubMed] [Google Scholar]
- PICKFORD M. Factors affecting milk release in the dog and the quantity of oxytocin liberated by suckling. J Physiol. 1960 Jul;152:515–526. doi: 10.1113/jphysiol.1960.sp006506. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Pickford M. The action of acetylcholine in the supraoptic nucleus of the chloralosed dog. J Physiol. 1947 Jul 31;106(3):264–270. doi: 10.1113/jphysiol.1947.sp004209. [DOI] [PMC free article] [PubMed] [Google Scholar]
- THEOBALD G. W. The separate release of oxytocin and antidiuretic hormone. J Physiol. 1959 Dec;149:443–461. doi: 10.1113/jphysiol.1959.sp006351. [DOI] [PMC free article] [PubMed] [Google Scholar]
- VOGT M. Vasopressor, antidiuretic, and oxytocic activities of extracts of the dog's hypothalamus. Br J Pharmacol Chemother. 1953 Jun;8(2):193–196. doi: 10.1111/j.1476-5381.1953.tb00777.x. [DOI] [PMC free article] [PubMed] [Google Scholar]